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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis
|
|---|---|
| Published in |
The Journal of Experimental Medicine, November 2013
|
| DOI | 10.1084/jem.20131241 |
| Pubmed ID | |
| Authors |
Stephen W. Scally, Jan Petersen, Soi Cheng Law, Nadine L. Dudek, Hendrik J. Nel, Khai Lee Loh, Lakshmi C. Wijeyewickrema, Sidonia B.G. Eckle, Jurgen van Heemst, Robert N. Pike, James McCluskey, Rene E. Toes, Nicole L. La Gruta, Anthony W. Purcell, Hugh H. Reid, Ranjeny Thomas, Jamie Rossjohn |
| Abstract |
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*04:02 allomorph interacted with arginine or citrulline-containing epitopes. Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04. Citrullination altered protease susceptibility of vimentin, thereby generating self-epitopes that are presented to T cells in HLA-DRB1*04:01(+) individuals. Using HLA-II tetramers, we observed citrullinated vimentin- and aggrecan-specific CD4(+) T cells in the peripheral blood of HLA-DRB1*04:01(+) RA-affected and healthy individuals. In RA patients, autoreactive T cell numbers correlated with disease activity and were deficient in regulatory T cells relative to healthy individuals. These findings reshape our understanding of the association between citrullination, the HLA-DRB1 locus, and T cell autoreactivity in RA. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 386 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Sweden | 1 | <1% |
| Hungary | 1 | <1% |
| Denmark | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 374 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 66 | 17% |
| Student > Ph. D. Student | 64 | 17% |
| Student > Master | 58 | 15% |
| Student > Bachelor | 49 | 13% |
| Student > Doctoral Student | 17 | 4% |
| Other | 57 | 15% |
| Unknown | 75 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 84 | 22% |
| Immunology and Microbiology | 62 | 16% |
| Medicine and Dentistry | 61 | 16% |
| Biochemistry, Genetics and Molecular Biology | 51 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 33 | 9% |
| Unknown | 85 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2022.
All research outputs
#2,887,961
of 26,017,215 outputs
Outputs from The Journal of Experimental Medicine
#1,950
of 11,726 outputs
Outputs of similar age
#26,321
of 232,297 outputs
Outputs of similar age from The Journal of Experimental Medicine
#14
of 57 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,726 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,297 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.