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Mendeley readers
Attention Score in Context
| Title |
Focal Adhesion Dynamics Are Altered in Schizophrenia
|
|---|---|
| Published in |
Biological Psychiatry, March 2013
|
| DOI | 10.1016/j.biopsych.2013.01.020 |
| Pubmed ID | |
| Authors |
Yongjun Fan, Greger Abrahamsen, Richard Mills, Claudia C. Calderón, Jing Yang Tee, Lisette Leyton, Wayne Murrell, Justin Cooper-White, John J. McGrath, Alan Mackay-Sim |
| Abstract |
Evidence from genetic association studies implicate genes involved in neural migration associated with schizophrenia risk. Neural stem/progenitor cell cultures (neurosphere-derived cells) from olfactory mucosa of schizophrenia patients have significantly dysregulated expression of genes in focal adhesion kinase (FAK) signaling, a key pathway regulating cell adhesion and migration. The aim of this study was to investigate whether olfactory neurosphere-derived cells from schizophrenia patients have altered cell adhesion, cell motility, and focal adhesion dynamics. Olfactory neurosphere-derived cells from nine male schizophrenia patients and nine male healthy control subjects were used. Cells were assayed for cell adhesion and cell motility and analyzed for integrins and FAK proteins. Focal adhesions were counted and measured in fixed cells, and time-lapse imaging was used to assess cell motility and focal adhesion dynamics. Patient-derived cells were less adhesive and more motile than cells derived from healthy control subjects, and their motility was reduced to control cell levels by integrin-blocking antibodies and by inhibition of FAK. Vinculin-stained focal adhesion complexes were significantly smaller and fewer in patient cells. Time-lapse imaging of cells expressing FAK tagged with green fluorescent protein revealed that the disassembly of focal adhesions was significantly faster in patient cells. The evidence for altered motility and focal adhesion dynamics in patient-derived cells is consistent with dysregulated gene expression in the FAK signaling pathway in these cells. Alterations in cell adhesion dynamics and cell motility could bias the trajectory of brain development in schizophrenia. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 1% |
| Greece | 1 | 1% |
| Unknown | 77 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 23% |
| Student > Ph. D. Student | 13 | 16% |
| Student > Bachelor | 12 | 15% |
| Student > Master | 9 | 11% |
| Professor | 5 | 6% |
| Other | 13 | 16% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 22% |
| Medicine and Dentistry | 15 | 19% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Neuroscience | 7 | 9% |
| Psychology | 4 | 5% |
| Other | 9 | 11% |
| Unknown | 16 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2013.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Biological Psychiatry
#5,190
of 6,596 outputs
Outputs of similar age
#134,114
of 207,743 outputs
Outputs of similar age from Biological Psychiatry
#67
of 89 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,596 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,743 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.