You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microbials for the production of monoclonal antibodies and antibody fragments
|
|---|---|
| Published in |
Trends in Biotechnology, October 2013
|
| DOI | 10.1016/j.tibtech.2013.10.002 |
| Pubmed ID | |
| Authors |
Oliver Spadiut, Simona Capone, Florian Krainer, Anton Glieder, Christoph Herwig |
| Abstract |
Monoclonal antibodies (mAbs) and antibody fragments represent the most important biopharmaceutical products today. Because full length antibodies are glycosylated, mammalian cells, which allow human-like N-glycosylation, are currently used for their production. However, mammalian cells have several drawbacks when it comes to bioprocessing and scale-up, resulting in long processing times and elevated costs. By contrast, antibody fragments, that are not glycosylated but still exhibit antigen binding properties, can be produced in microbial organisms, which are easy to manipulate and cultivate. In this review, we summarize recent advances in the expression systems, strain engineering, and production processes for the three main microbials used in antibody and antibody fragment production, namely Saccharomyces cerevisiae, Pichia pastoris, and Escherichia coli. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 36% |
| India | 1 | 7% |
| Chile | 1 | 7% |
| Australia | 1 | 7% |
| Unknown | 6 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 71% |
| Scientists | 3 | 21% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 632 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | <1% |
| United Kingdom | 3 | <1% |
| Colombia | 2 | <1% |
| United States | 2 | <1% |
| Austria | 2 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 612 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 121 | 19% |
| Student > Ph. D. Student | 106 | 17% |
| Student > Master | 102 | 16% |
| Researcher | 82 | 13% |
| Student > Doctoral Student | 21 | 3% |
| Other | 71 | 11% |
| Unknown | 129 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 172 | 27% |
| Biochemistry, Genetics and Molecular Biology | 153 | 24% |
| Engineering | 39 | 6% |
| Chemical Engineering | 29 | 5% |
| Immunology and Microbiology | 25 | 4% |
| Other | 79 | 13% |
| Unknown | 135 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2024.
All research outputs
#1,869,630
of 25,420,980 outputs
Outputs from Trends in Biotechnology
#253
of 2,861 outputs
Outputs of similar age
#17,111
of 225,985 outputs
Outputs of similar age from Trends in Biotechnology
#1
of 21 outputs
Altmetric has tracked 25,420,980 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,861 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,985 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.