Title |
MicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression
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Published in |
Human Pathology, April 2017
|
DOI | 10.1016/j.humpath.2017.03.017 |
Pubmed ID | |
Authors |
Suja Pillai, Chung Y. Lo, Victor Liew, Minella Lalloz, Robert A Smith, Vinod Gopalan, Alfred King-Yin Lam |
Abstract |
This study aims to examine the expression profiles of the miR-183 cluster (miR-96/182/183) in pheochromocytoma. Pheochromocytoma tissues were prospectively collected from 50 patients with pheochromocytoma. Expression of miR-183 cluster members and SDHB protein expression were analysed in these tissues by quantitative real-time polymerase chain reaction and immunohistochemistry respectively. The expression of miR-183 cluster members in pheochromocytomas was correlated with the clinical and pathological parameters of these patients. The expression levels of miR-183 cluster members were predominantly downregulated or deleted in pheochromocytoma. Low expression or deletion of miR-96 was predominantly noted in younger age patients with pheochromocytoma (<50years, P=.01). Female patients in the study group showed marked deletion of miR-182 (P=.05). Deletion of the cluster was also associated with SDHB protein expression in pheochromocytoma. Moreover, patients with low miR-183 cluster expression had a slightly better survival rate when compared to patients with high expression. To conclude, the findings indicate a role for miR-183 cluster members in the pathogenesis and clinical progression of pheochromocytoma. |
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Country | Count | As % |
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United States | 2 | 14% |
Peru | 1 | 7% |
Turkey | 1 | 7% |
Malaysia | 1 | 7% |
Unknown | 9 | 64% |
Demographic breakdown
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Scientists | 3 | 21% |
Practitioners (doctors, other healthcare professionals) | 3 | 21% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
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Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 14% |
Student > Bachelor | 2 | 14% |
Researcher | 2 | 14% |
Student > Master | 2 | 14% |
Other | 2 | 14% |
Unknown | 1 | 7% |
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Biochemistry, Genetics and Molecular Biology | 3 | 21% |
Social Sciences | 1 | 7% |
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Unknown | 3 | 21% |