| Title |
Identification and Determination of Selenoneine, 2-Selenyl-Nα, Nα, Nα-Trimethyl-l-Histidine, as the Major Organic Selenium in Blood Cells in a Fish-Eating Population on Remote Japanese Islands
|
|---|---|
| Published in |
Biological Trace Element Research, November 2013
|
| DOI | 10.1007/s12011-013-9846-x |
| Pubmed ID | |
| Authors |
Michiaki Yamashita, Yumiko Yamashita, Tetsuo Ando, Junji Wakamiya, Suminori Akiba |
| Abstract |
Selenoneine is the major selenium compound in fish muscles, and fish appears to be an important source of selenium in the fish-eating population. Selenoneine has strong antioxidant activity and a detoxifying function against methylmercury (MeHg) toxicity. Dietary intake, bioaccumulation, and metabolism of selenoneine have not been characterized in humans. A nutritional survey was conducted in remote islands of the Kagoshima Prefecture in Japan. To evaluate the potential risks and benefits of fish consumption for health, we measured concentrations of selenoneine, total selenium, MeHg, inorganic mercury, and polyunsaturated fatty acid (LC-PUFA) in the blood of a fish-eating human population. The erythrocyte, leukocyte, and platelet residues following removal of serum (cellular fraction) contained 0.510 μg Se/g, 0.212 μg selenoneine Se/g, and 0.262 μg Se-containing proteins Se/g, whereas the serum contained 0.174 μg total Se/g. Selenoneine was highly concentrated in the cellular fraction in a manner that was dependent on subjects' frequency of fish consumption. Concentrations of selenoneine were closely correlated with concentrations of MeHg in the cellular fraction. Selenoneine is the major chemical form of selenium in the blood cells of this fish-eating human population and may be an important biomarker for selenium redox status. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Spain | 1 | 1% |
| Kenya | 1 | 1% |
| France | 1 | 1% |
| Unknown | 68 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 19% |
| Student > Ph. D. Student | 11 | 15% |
| Student > Master | 10 | 14% |
| Student > Doctoral Student | 5 | 7% |
| Other | 5 | 7% |
| Other | 13 | 18% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 21% |
| Chemistry | 11 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Medicine and Dentistry | 6 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 20 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2022.
All research outputs
#7,402,040
of 23,299,593 outputs
Outputs from Biological Trace Element Research
#453
of 2,078 outputs
Outputs of similar age
#69,515
of 217,309 outputs
Outputs of similar age from Biological Trace Element Research
#17
of 38 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,078 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 217,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.