Title |
Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum
|
---|---|
Published in |
Journal of Infectious Diseases, July 2013
|
DOI | 10.1093/infdis/jit309 |
Pubmed ID | |
Authors |
Christopher L. Peatey, Jolanta A. Watson, Katharine R. Trenholme, Christopher L. Brown, Lars Nielson, Marko Guenther, Nicholas Timmins, Gregory S. Watson, Donald L. Gardiner |
Abstract |
Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 52 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 31% |
Student > Ph. D. Student | 16 | 30% |
Student > Master | 4 | 7% |
Student > Bachelor | 2 | 4% |
Student > Doctoral Student | 2 | 4% |
Other | 4 | 7% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 31% |
Biochemistry, Genetics and Molecular Biology | 13 | 24% |
Immunology and Microbiology | 4 | 7% |
Medicine and Dentistry | 3 | 6% |
Computer Science | 2 | 4% |
Other | 4 | 7% |
Unknown | 11 | 20% |