Title |
Deep conservation of cis-regulatory elements in metazoans
|
---|---|
Published in |
Philosophical Transactions of the Royal Society B: Biological Sciences, December 2013
|
DOI | 10.1098/rstb.2013.0020 |
Pubmed ID | |
Authors |
Ignacio Maeso, Manuel Irimia, Juan J. Tena, Fernando Casares, José Luis Gómez-Skarmeta |
Abstract |
Despite the vast morphological variation observed across phyla, animals share multiple basic developmental processes orchestrated by a common ancestral gene toolkit. These genes interact with each other building complex gene regulatory networks (GRNs), which are encoded in the genome by cis-regulatory elements (CREs) that serve as computational units of the network. Although GRN subcircuits involved in ancient developmental processes are expected to be at least partially conserved, identification of CREs that are conserved across phyla has remained elusive. Here, we review recent studies that revealed such deeply conserved CREs do exist, discuss the difficulties associated with their identification and describe new approaches that will facilitate this search. |
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Country | Count | As % |
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Spain | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Germany | 2 | 2% |
Spain | 1 | <1% |
Thailand | 1 | <1% |
Unknown | 96 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 26 | 25% |
Researcher | 22 | 22% |
Student > Master | 10 | 10% |
Student > Bachelor | 7 | 7% |
Professor > Associate Professor | 5 | 5% |
Other | 16 | 16% |
Unknown | 16 | 16% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 30 | 29% |
Computer Science | 2 | 2% |
Environmental Science | 1 | <1% |
Earth and Planetary Sciences | 1 | <1% |
Other | 3 | 3% |
Unknown | 20 | 20% |