| Title |
Prevalence of cortical superficial siderosis in patients with cognitive impairment
|
|---|---|
| Published in |
Journal of Neurology, November 2013
|
| DOI | 10.1007/s00415-013-7181-y |
| Pubmed ID | |
| Authors |
Frank Arne Wollenweber, Katharina Buerger, Claudia Mueller, Birgit Ertl-Wagner, Rainer Malik, Martin Dichgans, Jennifer Linn, Christian Opherk |
| Abstract |
Cortical superficial siderosis (cSS) is a magnetic resonance imaging marker of cerebral amyloid angiopathy (CAA) and can be its sole imaging sign. cSS has further been identified as a risk marker for future intracranial hemorrhage. Although uncommon in the general population, cSS may be much more prevalent in high risk populations for amyloid pathology. We aimed to determine the frequency of cSS in patients with cognitive impairment presenting to a memory clinic. We prospectively evaluated consecutive patients presenting to our memory clinic between April 2011 and April 2013. Subjects received neuropsychological testing using the Consortium to Establish a Registry for Alzheimer's Disease battery (CERAD-NP). Two hundred and twelve patients with documented cognitive impairment further underwent a standardized 3T-MR-imaging protocol with T2*-weighted gradient-echo sequences for detection of cSS. Thirteen of 212 patients (6.1 %) displayed cSS. In seven of them (54 %) cSS was the only imaging sign of CAA. Patients with cSS did not differ from patients without cSS with regard to medical history, age or cardiovascular risk profile. Subjects with cSS performed worse in the mini-mental state examination (p = 0.001), showed more white matter hyperintensities (p = 0.005) and more often had microbleeds (p = 0.001) compared to those without cSS. cSS is common in patients with cognitive impairment. It is associated with lower cognitive scores, white matter hyperintensities and microbleeds and can be the only imaging sign for CAA in this patient group. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 20% |
| Student > Ph. D. Student | 9 | 16% |
| Student > Master | 7 | 13% |
| Student > Postgraduate | 4 | 7% |
| Student > Doctoral Student | 4 | 7% |
| Other | 6 | 11% |
| Unknown | 15 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 32% |
| Psychology | 8 | 14% |
| Agricultural and Biological Sciences | 4 | 7% |
| Neuroscience | 4 | 7% |
| Nursing and Health Professions | 2 | 4% |
| Other | 3 | 5% |
| Unknown | 17 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2019.
All research outputs
#20,210,424
of 22,731,677 outputs
Outputs from Journal of Neurology
#3,964
of 4,458 outputs
Outputs of similar age
#184,988
of 212,391 outputs
Outputs of similar age from Journal of Neurology
#25
of 44 outputs
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