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A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

Overview of attention for article published in Nature Genetics, November 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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Title
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Published in
Nature Genetics, November 2013
DOI 10.1038/ng.2830
Pubmed ID
Authors

Klaus Bønnelykke, Patrick Sleiman, Kasper Nielsen, Eskil Kreiner-Møller, Josep M Mercader, Danielle Belgrave, Herman T den Dekker, Anders Husby, Astrid Sevelsted, Grissel Faura-Tellez, Li Juel Mortensen, Lavinia Paternoster, Richard Flaaten, Anne Mølgaard, David E Smart, Philip F Thomsen, Morten A Rasmussen, Silvia Bonàs-Guarch, Claus Holst, Ellen A Nohr, Rachita Yadav, Michael E March, Thomas Blicher, Peter M Lackie, Vincent W V Jaddoe, Angela Simpson, John W Holloway, Liesbeth Duijts, Adnan Custovic, Donna E Davies, David Torrents, Ramneek Gupta, Mads V Hollegaard, David M Hougaard, Hakon Hakonarson, Hans Bisgaard

Abstract

Asthma exacerbations are among the most frequent causes of hospitalization during childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide association study of a specific asthma phenotype characterized by recurrent, severe exacerbations occurring between 2 and 6 years of age in a total of 1,173 cases and 2,522 controls. Cases were identified from national health registries of hospitalization, and DNA was obtained from the Danish Neonatal Screening Biobank. We identified five loci with genome-wide significant association. Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. We also obtained strong evidence for a new susceptibility gene, CDHR3 (encoding cadherin-related family member 3), which is highly expressed in airway epithelium. These results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 347 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
United Kingdom 2 <1%
Netherlands 1 <1%
Norway 1 <1%
Germany 1 <1%
Finland 1 <1%
Brazil 1 <1%
Australia 1 <1%
Mexico 1 <1%
Other 3 <1%
Unknown 330 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 81 23%
Researcher 76 22%
Student > Master 26 7%
Student > Doctoral Student 22 6%
Student > Bachelor 21 6%
Other 69 20%
Unknown 52 15%
Readers by discipline Count As %
Medicine and Dentistry 88 25%
Agricultural and Biological Sciences 73 21%
Biochemistry, Genetics and Molecular Biology 55 16%
Immunology and Microbiology 32 9%
Computer Science 5 1%
Other 26 7%
Unknown 68 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 191. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2024.
All research outputs
#194,853
of 24,380,426 outputs
Outputs from Nature Genetics
#330
of 7,403 outputs
Outputs of similar age
#1,702
of 312,258 outputs
Outputs of similar age from Nature Genetics
#3
of 69 outputs
Altmetric has tracked 24,380,426 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,403 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,258 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.