| Title |
Risk and protective factors for structural brain ageing in the eighth decade of life
|
|---|---|
| Published in |
Brain Structure and Function, April 2017
|
| DOI | 10.1007/s00429-017-1414-2 |
| Pubmed ID | |
| Authors |
Stuart J. Ritchie, Elliot M. Tucker-Drob, Simon R. Cox, David Alexander Dickie, Maria del C. Valdés Hernández, Janie Corley, Natalie A. Royle, Paul Redmond, Susana Muñoz Maniega, Alison Pattie, Benjamin S. Aribisala, Adele M. Taylor, Toni-Kim Clarke, Alan J. Gow, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary |
| Abstract |
Individuals differ markedly in brain structure, and in how this structure degenerates during ageing. In a large sample of human participants (baseline n = 731 at age 73 years; follow-up n = 488 at age 76 years), we estimated the magnitude of mean change and variability in changes in MRI measures of brain macrostructure (grey matter, white matter, and white matter hyperintensity volumes) and microstructure (fractional anisotropy and mean diffusivity from diffusion tensor MRI). All indices showed significant average change with age, with considerable heterogeneity in those changes. We then tested eleven socioeconomic, physical, health, cognitive, allostatic (inflammatory and metabolic), and genetic variables for their value in predicting these differences in changes. Many of these variables were significantly correlated with baseline brain structure, but few could account for significant portions of the heterogeneity in subsequent brain change. Physical fitness was an exception, being correlated both with brain level and changes. The results suggest that only a subset of correlates of brain structure are also predictive of differences in brain ageing. |
X Demographics
The data shown below were collected from the profiles of 61 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 20 | 33% |
| United States | 7 | 11% |
| Germany | 4 | 7% |
| Canada | 2 | 3% |
| Bosnia and Herzegovina | 1 | 2% |
| Mexico | 1 | 2% |
| Turkey | 1 | 2% |
| Russia | 1 | 2% |
| Finland | 1 | 2% |
| Other | 7 | 11% |
| Unknown | 16 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 37 | 61% |
| Scientists | 20 | 33% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | <1% |
| Unknown | 102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 16% |
| Student > Master | 13 | 13% |
| Researcher | 12 | 12% |
| Student > Doctoral Student | 11 | 11% |
| Student > Bachelor | 9 | 9% |
| Other | 15 | 15% |
| Unknown | 27 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 23 | 22% |
| Neuroscience | 14 | 14% |
| Medicine and Dentistry | 11 | 11% |
| Social Sciences | 4 | 4% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 15 | 15% |
| Unknown | 33 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2018.
All research outputs
#1,173,979
of 25,196,456 outputs
Outputs from Brain Structure and Function
#60
of 1,753 outputs
Outputs of similar age
#23,112
of 316,224 outputs
Outputs of similar age from Brain Structure and Function
#1
of 48 outputs
Altmetric has tracked 25,196,456 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,753 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,224 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.