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Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Overview of attention for article published in ACS Applied Materials & Interfaces, September 2015
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Title
Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery
Published in
ACS Applied Materials & Interfaces, September 2015
DOI 10.1021/acsami.5b07365
Pubmed ID
Authors

Yevhen Fatieiev, Jonas G. Croissant, Shahad Alsaiari, Basem A. Moosa, Dalaver H. Anjum, Niveen M. Khashab

Abstract

Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale -unlike most reported bridged silsesquioxane materials- with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

X Demographics

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Saudi Arabia 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Researcher 5 16%
Student > Bachelor 4 13%
Other 2 6%
Student > Doctoral Student 2 6%
Other 2 6%
Unknown 9 29%
Readers by discipline Count As %
Chemistry 13 42%
Materials Science 3 10%
Engineering 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Nursing and Health Professions 1 3%
Other 1 3%
Unknown 9 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2017.
All research outputs
#18,542,806
of 22,965,074 outputs
Outputs from ACS Applied Materials & Interfaces
#11,899
of 17,471 outputs
Outputs of similar age
#197,882
of 274,810 outputs
Outputs of similar age from ACS Applied Materials & Interfaces
#207
of 296 outputs
Altmetric has tracked 22,965,074 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 17,471 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,810 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 296 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.