Title |
Biodegradable Oxamide‐Phenylene‐Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
|
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Published in |
Chemistry - A European Journal, June 2016
|
DOI | 10.1002/chem.201601714 |
Pubmed ID | |
Authors |
Jonas G. Croissant, Yevhen Fatieiev, Khachatur Julfakyan, Jie Lu, Abdul‐Hamid Emwas, Dalaver H. Anjum, Haneen Omar, Fuyuhiko Tamanoi, Jeffrey I. Zink, Niveen M. Khashab |
Abstract |
We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Saudi Arabia | 1 | 2% |
Unknown | 57 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 17% |
Researcher | 8 | 14% |
Student > Bachelor | 8 | 14% |
Student > Doctoral Student | 6 | 10% |
Student > Master | 5 | 8% |
Other | 7 | 12% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 24 | 41% |
Materials Science | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Agricultural and Biological Sciences | 2 | 3% |
Other | 6 | 10% |
Unknown | 18 | 31% |