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Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana

Overview of attention for article published in PLOS ONE, April 2017
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Title
Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana
Published in
PLOS ONE, April 2017
DOI 10.1371/journal.pone.0175388
Pubmed ID
Authors

Linda Ahenkorah Fondjo, William K. B. A. Owiredu, Samuel Asamoah Sakyi, Edwin Ferguson Laing, Michael Acquaye Adotey-Kwofie, Enoch Odame Antoh, Eric Detoh

Abstract

Vitamin D plays a major role in physiological processes that modulate mineral metabolism and immune function with probable link to several chronic and infectious conditions. Emerging data suggests a possible influence of vitamin D on glucose homeostasis. This study sought to provide preliminary information on vitamin D status among Ghanaian type 2 diabetics and assessed its association with glucose homeostasis. In a case control study, 118 clinically diagnosed Type 2 Diabetes Mellitus (T2DM) patients attending Diabetic Clinic at the Nkawie Government Hospital were enrolled between October and December 2015. Hundred healthy non-diabetics living in Nkawie district were selected as controls. Structured questionnaires were administered to obtain socio-demographic data. Venous blood samples were taken from both cases and controls to estimate their FBG, Lipid profile spectrophotometrically and IPTH, 25OHD by ELISA. Statistical analyses were performed using SPSS v20.0 Statistics. The average age of the study participants was 58.81years for cases and 57.79year for controls. There was vitamin D deficiency of 92.4% among T2DM cases and 60.2% among the non diabetic controls. Vitamin D deficiency did not significantly associate with HOMA-β [T2DM: r2 = 0.0209, p = 0.1338 and Control: r2 = 0.0213, p = 0.2703] and HOMA-IR [T2DM: r2 = 0.0233, p = 0.1132 and Control: r2 = 0.0214, p = 0.2690] in both the controls and the cases. Vitamin D deficiency is prevalent in both T2DM and non-diabetics. There is no association between vitamin D deficiency and insulin resistance or beta cell function in our study population. Vitamin D supplementation among type 2 diabetics is recommended.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ghana 1 <1%
Unknown 124 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 16%
Student > Bachelor 19 15%
Other 9 7%
Student > Ph. D. Student 8 6%
Student > Postgraduate 7 6%
Other 18 14%
Unknown 44 35%
Readers by discipline Count As %
Medicine and Dentistry 35 28%
Nursing and Health Professions 15 12%
Biochemistry, Genetics and Molecular Biology 9 7%
Agricultural and Biological Sciences 4 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 11 9%
Unknown 49 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2017.
All research outputs
#20,944,189
of 23,577,761 outputs
Outputs from PLOS ONE
#181,135
of 202,084 outputs
Outputs of similar age
#271,650
of 311,583 outputs
Outputs of similar age from PLOS ONE
#4,052
of 4,596 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 202,084 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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