Title |
Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion
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Published in |
European Journal of Nutrition, June 2013
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DOI | 10.1007/s00394-013-0542-6 |
Pubmed ID | |
Authors |
Simona Dinicola, Alessia Pasqualato, Alessandra Cucina, Pierpaolo Coluccia, Francesca Ferranti, Rita Canipari, Angela Catizone, Sara Proietti, Fabrizio D’Anselmi, Giulia Ricci, Alessandro Palombo, Mariano Bizzarri |
Abstract |
Breast cancer remains a leading cause of mortality among women. In metastasis, cascade migration of cancer cells and invasion of extracellular matrix (ECM) represent critical steps. Urokinase-type plasminogen activator (uPA), as well as metalloproteinases MMP-2 and MMP-9, strongly contribute to ECM remodelling, thus becoming associated with tumour migration and invasion. In addition, the high expression of cytoskeletal (CSK) proteins, as fascin, has been correlated with clinically aggressive metastatic tumours, and CSK proteins are thought to affect the migration of cancer cells. Consumption of fruits and vegetables, characterized by high procyanidin content, has been associated to a reduced mortality for breast cancer. Therefore, we investigated the biological effect of grape seed extract (GSE) on the highly metastatic MDA-MB231 breast cancer cell line, focusing on studying GSE ability in inhibiting two main metastatic processes, i.e., cell migration and invasion. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 12% |
Other | 5 | 10% |
Researcher | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Student > Bachelor | 4 | 8% |
Other | 8 | 16% |
Unknown | 16 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Medicine and Dentistry | 7 | 14% |
Agricultural and Biological Sciences | 3 | 6% |
Nursing and Health Professions | 3 | 6% |
Arts and Humanities | 2 | 4% |
Other | 6 | 12% |
Unknown | 20 | 41% |