| Title |
Age-associated telomere shortening in mouse oocytes
|
|---|---|
| Published in |
Reproductive Biology and Endocrinology, November 2013
|
| DOI | 10.1186/1477-7827-11-108 |
| Pubmed ID | |
| Authors |
Tomoko Yamada-Fukunaga, Mitsutoshi Yamada, Toshio Hamatani, Nana Chikazawa, Seiji Ogawa, Hidenori Akutsu, Takumi Miura, Kenji Miyado, Juan J Tarín, Naoaki Kuji, Akihiro Umezawa, Yasunori Yoshimura |
| Abstract |
Oocytes may undergo two types of aging. The first is induced by exposure to an aged ovarian microenvironment before being ovulated, known as 'reproductive or maternal aging', and the second by either a prolonged stay in the oviduct before fertilization or in vitro aging prior to insemination, known as 'postovulatory aging'. However, the molecular mechanisms underlying these aging processes remain to be elucidated. As telomere shortening in cultured somatic cells triggers replicative senescence, telomere shortening in oocytes during reproductive and postovulatory aging may predict developmental competence. This study aimed to ascertain the mechanisms underlying altered telomere biology in mouse oocytes during reproductive and postovulatory aging. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 20% |
| Researcher | 13 | 16% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 13 | 16% |
| Unknown | 18 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 35% |
| Biochemistry, Genetics and Molecular Biology | 15 | 18% |
| Medicine and Dentistry | 9 | 11% |
| Environmental Science | 3 | 4% |
| Neuroscience | 3 | 4% |
| Other | 3 | 4% |
| Unknown | 20 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2013.
All research outputs
#20,210,424
of 22,731,677 outputs
Outputs from Reproductive Biology and Endocrinology
#828
of 966 outputs
Outputs of similar age
#262,667
of 301,953 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#34
of 38 outputs
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