| Title |
Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats
|
|---|---|
| Published in |
Archives of Toxicology, July 2007
|
| DOI | 10.1007/s00204-006-0170-5 |
| Pubmed ID | |
| Authors |
Eliane Dallegrave, Fabiana D. Mantese, Rosemari T. Oliveira, Anderson J. M. Andrade, Paulo R. Dalsenter, Augusto Langeloh |
| Abstract |
Glyphosate is the active ingredient and polyoxyethyleneamine is the surfactant present in the herbicide Roundup formulation commercialized in Brazil. The aim of this study was to assess the reproductive effects of glyphosate-Roundup on male and female offspring of Wistar rats exposed during pregnancy and lactation. Dams were treated orally with water or 50, 150 or 450 mg/kg glyphosate during pregnancy (21-23 days) and lactation (21 days). These doses do not correspond to human exposure levels. The results showed that glyphosate-Roundup did not induce maternal toxicity but induced adverse reproductive effects on male offspring rats: a decrease in sperm number per epididymis tail and in daily sperm production during adulthood, an increase in the percentage of abnormal sperms and a dose-related decrease in the serum testosterone level at puberty, and signs of individual spermatid degeneration during both periods. There was only a vaginal canal-opening delay in the exposed female offspring. These findings suggest that in utero and lactational exposure to glyphosate-Roundup may induce significant adverse effects on the reproductive system of male Wistar rats at puberty and during adulthood. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 1% |
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 140 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 26 | 18% |
| Student > Bachelor | 16 | 11% |
| Student > Doctoral Student | 14 | 10% |
| Researcher | 14 | 10% |
| Student > Ph. D. Student | 13 | 9% |
| Other | 19 | 13% |
| Unknown | 44 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 18% |
| Biochemistry, Genetics and Molecular Biology | 19 | 13% |
| Medicine and Dentistry | 16 | 11% |
| Environmental Science | 9 | 6% |
| Veterinary Science and Veterinary Medicine | 6 | 4% |
| Other | 20 | 14% |
| Unknown | 49 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2022.
All research outputs
#1,926,055
of 24,366,830 outputs
Outputs from Archives of Toxicology
#126
of 2,758 outputs
Outputs of similar age
#3,761
of 70,029 outputs
Outputs of similar age from Archives of Toxicology
#2
of 9 outputs
Altmetric has tracked 24,366,830 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,758 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,029 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.