| Title |
Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease
|
|---|---|
| Published in |
Neurochemical Research, April 2008
|
| DOI | 10.1007/s11064-008-9657-1 |
| Pubmed ID | |
| Authors |
J. Cameron Thrash, Bruce E. Torbett, Monica J. Carson |
| Abstract |
Trem2 is an orphan, DAP12 associated receptor constitutively expressed in vivo by subsets of microglia in the healthy adult murine CNS and in vitro by subsets of oligodendrocytes in neonatal mixed glial cultures. Loss of a functional Trem2 signaling pathway is the genetic cause of Nasu-Hakola disease. Whether the early onset cognitive dementia and myelin-pallor associated with this disorder are due to deficits in functional Trem2 signaling in microglia and/or oligodendrocytes is still being debated. Here, we find that Trem2/DAP12 expression is detected in embryonic day 14 CNS mRNA. Using dual immunohistochemistry/in situ hybridization, we find that both Trem2 and DAP12 expression always co-localized with markers of microglia/macrophages. However, Trem2/DAP12 positive microglia are found in very close apposition with CNP+ oligodendrocytes prior to myelination (post-natal day 1). In addition, CNS expression of TREM2 and DAP12 are not detected in PU.1KO which lack microglia and macrophages. Our data provide continuing support for Nasu-Hakola disease being identified as a cognitive disorder caused by a primary dysfunction of CNS microglia. |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 59 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 31% |
| Researcher | 13 | 21% |
| Student > Bachelor | 10 | 16% |
| Other | 3 | 5% |
| Student > Master | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 34% |
| Neuroscience | 11 | 18% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Medicine and Dentistry | 4 | 7% |
| Other | 4 | 7% |
| Unknown | 8 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2021.
All research outputs
#3,222,346
of 22,731,677 outputs
Outputs from Neurochemical Research
#221
of 2,088 outputs
Outputs of similar age
#9,625
of 81,625 outputs
Outputs of similar age from Neurochemical Research
#2
of 28 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,088 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.