| Title |
Expression of Programmed Death-1 (PD-1) on CD4+ and CD8+ T cells in Rheumatoid Arthritis
|
|---|---|
| Published in |
Inflammation, September 2013
|
| DOI | 10.1007/s10753-013-9718-8 |
| Pubmed ID | |
| Authors |
Shufeng Li, Wensheng Liao, Meng Chen, Shiying Shan, Yuanlin Song, Shuzhen Zhang, Haihan Song, Zhen Yuan |
| Abstract |
Rheumatoid arthritis (RA) is characterized by chronic inflammatory process that targets the synovial lining of diarthrodial joints. Programmed death 1 (PD-1) plays a key role in the negative regulation of the immune response. In the current study, we investigated the expression of PD-1 on peripheral CD4+ and CD8+ T cells in RA patients. Percentage of PD-1+ cells was measured by flow cytometry in 82 RA cases and 90 healthy controls. Results showed that PD-1 expression was significantly decreased in both peripheral CD4+ and CD8+ T cells in RA (p = 0.002 and p < 0.001, respectively). Similarly, serum levels of soluble PD-1 were also downregulated in RA cases. When comparing PD-1 level in RA patients with different clinical parameters, patients with positive C-reactive protein (CRP) revealed lower proportion of PD-1 on CD4+ and CD8+ T cells than those with negative CRP. Also, disease activity score of RA patients was inversely correlated with PD-1 expression on peripheral CD4+ and CD8+ T cells. These data suggested that PD-1 may act as a negative regulator in the pathogenesis and progression of RA. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 23% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Researcher | 6 | 11% |
| Student > Doctoral Student | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 12 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 27% |
| Biochemistry, Genetics and Molecular Biology | 10 | 18% |
| Immunology and Microbiology | 9 | 16% |
| Agricultural and Biological Sciences | 8 | 14% |
| Chemistry | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 13 | 23% |
Attention Score in Context
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#20,210,424
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Outputs from Inflammation
#708
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#172,990
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Outputs of similar age from Inflammation
#12
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