| Title |
The Origins of Mesenchymal Stromal Cell Heterogeneity
|
|---|---|
| Published in |
Stem Cell Reviews and Reports, January 2011
|
| DOI | 10.1007/s12015-011-9229-7 |
| Pubmed ID | |
| Authors |
Meirav Pevsner-Fischer, Sarit Levin, Dov Zipori |
| Abstract |
Cultured mesenchymal stromal cell (MSC) populations are best characterized by the capacity of some cells within this population to differentiate into mesodermal derivatives such as osteoblasts, chondrocytes and adipocytes. However, this progenitor property is not shared by all cells within the MSC population. Furthermore, MSCs exhibit variability in their phenotypes, including proliferation capacity, expression of cell surface markers and ability to secrete cytokines. These facts raise three major questions: (1) Does the in vitro observed variability reflect the existence of MSC subsets in vivo? (2) What is the molecular basis of the in vitro observed heterogeneity? and (3) What is the biological significance of this variability? This review considers the possibility that the variable nature of MSC populations contributes to the capacity of adult mammalian tissues to adapt to varying microenvironmental demands. |
Mendeley readers
The data shown below were compiled from readership statistics for 230 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| Israel | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 222 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 66 | 29% |
| Researcher | 37 | 16% |
| Student > Master | 32 | 14% |
| Student > Bachelor | 20 | 9% |
| Student > Postgraduate | 12 | 5% |
| Other | 24 | 10% |
| Unknown | 39 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 30% |
| Medicine and Dentistry | 40 | 17% |
| Biochemistry, Genetics and Molecular Biology | 38 | 17% |
| Engineering | 13 | 6% |
| Chemistry | 8 | 3% |
| Other | 18 | 8% |
| Unknown | 45 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2015.
All research outputs
#7,356,343
of 25,374,917 outputs
Outputs from Stem Cell Reviews and Reports
#321
of 1,036 outputs
Outputs of similar age
#50,373
of 192,487 outputs
Outputs of similar age from Stem Cell Reviews and Reports
#12
of 16 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,036 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,487 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.