Understanding Biology Using Peptides

Table of Contents

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   Book Overview
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   Chapter 1 From Tens to Trillions - Advances in Synthetic Combinatorial Chemistry of Peptides, Peptidomimetics and Heterocyclic Compounds Derived from Peptides
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   Chapter 2 Peptides in the Days of Photonics
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   Chapter 3 It All Started in Brooklyn, NY, Forty-five Years Ago!
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   Chapter 4 Short Transmembrane Peptide Sequences as Nucleation Sites for Globular Protein Folding
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   Chapter 5 Synthesis and In Vitro Opioid Activity Profiles of Novel Cyclic Enkephalin Analogs
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   Chapter 6 A Photo-Controlled β-Hairpin
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   Chapter 7 Structure-Function Relationship Studies of Analogs of PTH(1–11) Fragment Containing Combinations of Aib and (αMe)Nle
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   Chapter 8 Membrane Associated Structure of a Ghrelin Agonist as Determined by NMR
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    Chapter 9 Scaffold, Dendritic and Metal-Assisted Assembly of Collagen-Like Biomaterials
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    Chapter 10 Positional Scanning for Peptide Secondary Structure by Solid Phase Synthesis with Aza-Amino Acids and Freidinger Lactams
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    Chapter 11 Synthesis of Cyclic Peptides via Transition Metal Catalyzed C-C Bond Formation
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    Chapter 12 Solid Phase Synthesis of Phosphorylated Cis and Trans 3-Peptidyl-4-(4′-hydroxyphenyl)-β-Lactams
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    Chapter 13 Switch on Amyloid β Peptide Self-Assembly by Enzyme-Triggered Acyl Migration
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    Chapter 14 ROMP of Norbornyl Oligopeptides: A Versatile Synthetic Method for Exploring Receptor Topology
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    Chapter 15 Native Chemical Ligation at Aromatic Residues
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    Chapter 16 Robotic Synthesis of Soluble Peptide Arrays
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    Chapter 17 Covalent Capture: Application to Peptides Possessing Auxiliary Groups for Extended Chemical Ligation
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    Chapter 18 Asymmetric Induction on a Racemic Amine by Chiral Dipeptide 5(4H)-Oxazolones from Cα-Methyl Phenylglycine
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    Chapter 19 Poly(ethylene glycol) (PEG) Modifications and Conformational Analysis of Thymosin α 1
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    Chapter 20 Suppression of Side Reactions Associated with Use of the Benzyloxymethyl Group on Histidine
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    Chapter 21 Peptide Synthesis in Water: 2-(4-Sulfophenylsulfonyl)ethoxycarbonyl Group and Coupling Reagents
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    Chapter 22 Efficient Synthesis in Solid-Phase of Freidinger-like Lactams by Microwave Irradiation
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    Chapter 23 Synthesis of Monocyte Chemoattractant Protein 1 (MCP-1) Analogs via Native Chemical Ligation
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    Chapter 24 NMR Analysis of a Multi-domain Peptide of the Saccharomyces cerevisiae Alpha Factor Receptor
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    Chapter 25 Further Studies on an Alternative Approach to Prepare Esterified Protected Peptides under Mild Conditions
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    Chapter 26 A Long Range S,N-Acyl Migration by Silver Ion Assistance in Thioester Ligation
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    Chapter 27 The C-Terminal Fragment of Acanthoscurrin is a Difficult Sequence
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    Chapter 28 A Novel Approach to Resin-based Cysteine Alkylation
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    Chapter 29 Deprotection of the p-Methoxybenzyl Group of Selenocysteine by Neighboring Group Participation
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    Chapter 30 Overcoming Challenges in Automated Long Peptide Synthesis — A Multi-pronged Approach
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    Chapter 31 Synthesis and Biological Evaluation of Antagonist Analogs of the Peptide Hormone Oxytocin
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    Chapter 32 Development of Wang Resin Supported Evans-type Oxazolidinone for Asymmetric Reaction
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    Chapter 33 A Convenient Synthetic Method for Monodehydro-2,5-diketopiperazines
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    Chapter 34 Solid-Phase Synthesis of Azole-Based Peptides and Peptidomimetics
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    Chapter 35 Efficient Synthesis of N-Methylamino Acids Compatible with Fmoc Solid-Phase Peptide Synthesis
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    Chapter 36 The “O-Acyl Isopeptide Method” for the Synthesis of Alzheimer’s Disease-Related Amyloid β Peptide (Aβ) 1–42
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    Chapter 37 The “O-Acyl Isopeptide Method” for the Synthesis of Difficult Sequence-Containing Peptides: Application to the Synthesis of Alzheimer’s Disease-Related Amyloid β Peptide (Aβ) 1–42 Mutants
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    Chapter 38 Enhancing Atom Economy of SPS: Recoverable and Reusable Building Blocks for Depsipeptide Synthesis
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    Chapter 39 1-N-Methyl-Histidine as a Side-Product in Backbone N-Methylated PTH Analogs
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    Chapter 40 Combinatorial Approach in the Synthesis of a Small Library of β-Turn Structures Based on Thiazolidine Moiety
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    Chapter 41 Solid-Phase Peptide Synthesis Using ChemMatrix®, a Polyethylenglycol (PEG)-based Solid
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    Chapter 42 Understanding Biology Using Peptides
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    Chapter 43 Synthesis and NMR Analysis of CCR5 and CXCR4 Peptides Containing Tyrosine Sulfate
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    Chapter 44 Steroid-Peptide Conjugates
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    Chapter 45 Influence of Natural Loop Residues or Oligolysines on the Biophysical Properties of Transmembrane Domains of a G Protein-Coupled Receptor
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    Chapter 46 Design, Synthesis and Analysis of Constrained B-Cell Epitope from HER-2 Protein
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    Chapter 47 Synthesis of the Four Stereoisomers of N-Fmoc-O-t-Bu-4,4,4- trifluorothreonine
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    Chapter 48 Synthesis of N α-Fmoc-N ε-[(2-nitrophenyl)acetyl]-lysine (Fmoc-Lys(Npa)-OH) and its Applications in Solid-Phase Peptide Synthesis
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    Chapter 49 A MS-based Encoding Method for OBOC Combinatorial Branched Peptide Libraries
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    Chapter 50 Sequential Chemical Ligation for Polypeptide Synthesis by the Combination of the Thioester Method and the Extended Chemical Ligation Using a Photoremovable Auxiliary
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    Chapter 51 Solid-Phase Synthesis of a Mucin Glycopeptide Segment from CD43 for NMR and Crystallization Studies
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    Chapter 52 SPPS of Bacterial Addressed Peptides and PNAs Overcoming the Resistance against Antibiotics
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    Chapter 53 Convergent Synthesis of the Cysteine-rich Mdm2 RING Finger Domain
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    Chapter 54 Evaluation of Polyamide-Polystyrene Block Polymers in Peptide Synthesis and Biochemistry
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    Chapter 55 New Nomenclature for Complex Cyclopeptides
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    Chapter 56 New Approaches for Native Chemical Ligation
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    Chapter 57 Microwave-Assisted Solid-Phase Peptide Synthesis (MW-SPPS) on CLEAR Supports
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    Chapter 58 Microwave Assisted Peptide Synthesis — A Tool to Replace Classical SPPS?
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    Chapter 59 Fast and Versatile Peptide Backbone Modifications Using Microwave Energy
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    Chapter 60 Microwave-Assisted Synthesis of Multivalent Dendrimeric Peptides using Cycloaddition Reaction (‘Click’) Chemistry
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    Chapter 61 Efficient Synthesis of Disulfide Bridge Containing Peptides: Melanin Concentrating Hormone (MCH) and Brain Natriuretic Peptide (BNP)
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    Chapter 62 Rapid Solution-phase Synthesis of a 20-mer Peptide According to the DioRaSSP® Method
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    Chapter 63 A New Efficient Post-Assembly Strategy for the Synthesis of Sulfated Peptides
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    Chapter 64 Auxiliary Group-Assisted Peptide Thioester Preparation Based on On-resin N-S Acyl Shift Triggered by TFA Treatment
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    Chapter 65 Determination of an Optimal Solid Support for Use with Microwave-Assisted Solid-Phase Peptide Synthesis
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    Chapter 66 Efficient Recombinant Production of the 16 Amino Acid Peptide AOD9604
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    Chapter 67 Chemical Synthesis of the Gsti Protein by a NCL Method on a X-Met Site
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    Chapter 68 N,O-Acyl Shifts: Unexpected Side-Reaction and Beneficial Tool in Fmoc-Chemistry
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    Chapter 69 Magnetic CLEAR Beads for Solid-Phase Synthesis of Peptides and Affinity Ligands
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    Chapter 70 An Efficient and Facile Synthesis of Tyrosine-Sulfate-Containing Peptides: Synthesis of the N-Terminal Peptide of CCR5 and Its Analog
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    Chapter 71 Interaction of DPH with the Local Anesthetic Receptor Site in D1-S6 of the Na+ Channel by NMR and Molecular Modeling
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    Chapter 72 The Structural Determinants of GPCR Binding and Activation: Insights from Mutagenesis and Molecular Modeling Studies of the Human Angiotensin II Type 1 (hAT1) Receptor
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    Chapter 73 Protein Epitope Mimetics A New Approach to Target Protein-Protein Interactions
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    Chapter 74 Application of Phenylphosphate Mimetics to the Design and Synthesis of Olefin Metathesis-Derived Grb2 SH2 Domain-Binding Macrocycles
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    Chapter 75 Radiolabeled Peptides as CXCR4 Ligands
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    Chapter 76 Aza-peptides with Multiple Aza-amino Acids, Synthesis and Preliminary Conformational Analysis of Glu-azaAla-Ala-azaAla-Leu-azaAla-Lys-azaAla-NH2
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    Chapter 77 Design and Synthesis of Bicyclic Internal β-Turn Mimetics and their Applications toward Biologically Interesting Ligands
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    Chapter 78 Synthesis and Incorporation of Freidinger Lactam Analogs in GHRP-6
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    Chapter 79 Microwave-assisted Synthesis of N-glycosylated Building Blocks
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    Chapter 80 Parallel Solid-Phase Synthesis of Mucin-Like Glycopeptides from an α-GalN3 O-Linked Threonine Building Block
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    Chapter 81 Synthesis of Silyl Ether Linkers for Solid-Phase Peptide Synthesis
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    Chapter 82 Synthetic Routes to, and Mechanistic Understanding of, Dithiasuccinoyl (Dts)-Amines and Chlorocarbonyl Carbamoyl Disulfanes
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    Chapter 83 Peptide-Derived (Sulfonyl)Azides as Versatile Synthons in Chemoselective Bioconjugations
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    Chapter 84 Chemically Synthesized Annexin-A5-Based Probes for Molecular Imaging
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    Chapter 85 Unequivocal Synthesis of (Z)-Alkene or (E)-Fluoroalkene Dipeptide Isosteres via DKP Mimetics to Probe Structural Requirements of Peptide Transporter
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    Chapter 86 Development of New Photoremovable Amino Protecting Group and its Application toward Chemical Synthesis of 7TM-GPCR
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    Chapter 87 Multivalent Peptide Dendrimers: Native Chemical Ligation as a Synthetic Tool
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    Chapter 88 Synthesis and Use of C-terminally Biotinylated Peptidomimetics with High Grb2 SH2 Domain-binding Affinity
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    Chapter 89 Total Solid Phase Synthesis of a Marine Cyclodepsipeptide IB-01212
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    Chapter 90 Interference with Protein-Protein Interactions Involved in Protease Inhibitor Complex Formation
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    Chapter 91 Sequence-Enabled Reassembly (SEER) Peptides for the Detection of DNA Sequences
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    Chapter 92 A Mild Acidic Method for the Selective Deprotection of N1-trityl-3a-hydroxypyrrolo[2,3-b]indole Derivatives
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    Chapter 93 Enantiomerically Pure H-Arg(Z)2-aldehyde Diethylacetal: A Useful Building Block in the Synthesis of Peptide Aldehydes
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    Chapter 94 Chlorotrityl Chloride (CTC) Resin as a Convenient Reusable Protecting Group
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    Chapter 95 Synthesis and Purification of Multiphosphorylated Peptides
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    Chapter 96 Dealing with the Aggregation Problem of Polyglutamine Peptides: Synthesis Strategies
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    Chapter 97 Synthesis and Biological Assessment of Insulin-Like Analogs with Differential Activity at the Insulin and IGF-1 Receptors
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    Chapter 98 Biosynthesis of the Cyclotide Kalata B1 using Protein Splicing Tools
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     Chapter 99 Exploration and Elaboration of Reported Insulin Superagonism through Site-Selective Replacement at TyrB26
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     Chapter 100 Synthesis of an RNase B 30—124 Glycoform by Native Chemical Ligation
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     Chapter 101 Threaded Rings and Complex Topologies in Antimicrobial Peptides: Nature’s Engineering Templates
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     Chapter 102 A Minimalist Approach to Antimicrobial Proteins with Thionin as a Template
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     Chapter 103 Discovering Additional Chemical and Biological Functions for 3-Oxo-N-Acylhomoserine Lactones
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     Chapter 104 Comparing Antimicrobial and Membrane Permeabilizing Activity of Peptides Derived from Human Cationic Proteins
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     Chapter 105 Preliminary NMR Analysis of ProP440–500 the C-Terminal Cytoplasmic Domain of Bacterial Osmosensory Protein ProP
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     Chapter 106 Synthesis and Conformation of Analogs of the Antiviral Peptide Halovir A
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     Chapter 107 Total Synthesis in Solution and Preliminary Conformational Analysis of TOAC-Labeled Alamethicin F50/5 Analogs
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     Chapter 108 A Lipid Monolayer Made Permeable to Tl(I) Ions by the Lipopeptaibol Trichogin GA IV
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     Chapter 109 A Universal Influenza B Peptide Vaccine
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     Chapter 110 Design, Synthesis and Analysis of a Cysteine-Deleted Analog of the Antimicrobial Peptide Tachyplesin-I
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     Chapter 111 Progress toward Total Solid-Phase Synthesis of Cyclic Lipodepsipeptide Antibiotic Fusaricidin A
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     Chapter 112 Biological and Structural Characterization of a New Linear Gomesin Analog
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     Chapter 113 Monomeric Analogs of Halocidin
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     Chapter 114 Fragment of Human Lysozyme Conjugated on the N-terminus and Displaying Antibacterial Properties
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     Chapter 115 Synthesis and Raman Spectroscopy Studies of the Antimicrobial Peptide Cecropin B2
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     Chapter 116 Alamethicin Interaction with Lipid Membranes: A Spectroscopic Study on Synthetic Analogs
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     Chapter 117 Design of Bactericidal Self-Assembling Cyclic D,L-α-Glycopeptides
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     Chapter 118 HB-50: A Pre-Clinical Study of a Prophylactic for Wound Infection
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     Chapter 119 Designer Multifunctional Antimicrobial Peptides Kill Fluoroquinolone-Resistant Clinical Isolates
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     Chapter 120 Solution Structures of Stomoxyn and Spinigerin, Two Antimicrobial Peptides from Insects
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     Chapter 121 Rational Design of α-Helical Antimicrobial Peptides
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     Chapter 122 Dimer Formation of Novel Cationic Antimicrobial Peptides in Membrane Environments
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     Chapter 123 Enzymatic Incorporation of Prenyl Azides into Peptides and Proteins: Tools for Selective Protein Labeling
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     Chapter 124 N-Alkylaminooxy Amino Acids as Versatile Derivatives for “Post-Translational” Modifications of Synthetic Peptides
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     Chapter 125 Improved Synthesis of 5-hydroxylysine (Hyl) Derivatives
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     Chapter 126 Synthesis and Biological Assessment of Sulfonic Acid-Based Glucagon Antagonists
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     Chapter 127 Thioester Bond Liability: Study on Natural Influenza and Model Acylpeptides
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     Chapter 128 Chemical Synthesis of MUC2 Tandem Repeat Model Carrying Multiple O-GalNAc Moieties
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     Chapter 129 Site Specific Introduction of Unnatural Amino Acids at Sites Critical to Insulin Receptor Recognition and Biological Activity
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     Chapter 130 Target-Based Proteolytic Profiling for Characterizing Cancer Progression
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     Chapter 131 From Simple Consensus Peptides to High Affinity Ligands: A Stepwise Diversity Oriented Strategy for the Acquisition of Potent Signaling Inhibitors
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     Chapter 132 Cyclic Modular β-Sheets
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     Chapter 133 Apolipoprotein A-I Mimetic Peptides
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     Chapter 134 Understanding BBB Transport using Glycosylated Enkephalins and Endorphins
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     Chapter 135 Design and Study of Novel Peptide Inhibitors against the SARS-Coronavirus Spike Protein
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     Chapter 136 Screening Biosynthetic Peptide Libraries for Antimicrobial Activity
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     Chapter 137 Cellular Delivery and Design of Proprotein Convertase Inhibitors
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     Chapter 138 Mechanism of Interaction between the (17–31) Binding Domain of PTH and the PTH Receptor
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     Chapter 139 [3,3]-Sigmatropic Rearrangments, and Chiral Aziridines for the Asymmetric Synthesis of Novel Amino Acids
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     Chapter 140 A Library of Cysteine-Biotine Derivatives Useful for Pretargeting Avidin-Biotin Radioimmunoscintigraphy
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     Chapter 141 A Methionine Scan of Region [168–176] of the Parathyroid Hormone Receptor 1 — The “Magnet Effect”
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     Chapter 142 A New Approach to the Synthesis of Policyclic Dipeptide Derivatives as Potential Antitumoral Agents
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     Chapter 143 A Purification Strategy for Synthetic Peptides that Utilizes pH to Optimize Selectivity
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     Chapter 144 Agonist Activation of the Angiotensin II Type 1 Receptor Alters the Spatial Proximity of Transmembrane Domain 7 to the Ligand Binding Pocket
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     Chapter 145 An Asymmetric Synthesis of (R)- and (S)-o-cyano-phenylalanine Leading to Chiral Constrained Phenylalanine Dipeptide Mimetics
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     Chapter 146 Analogs of Multifunctional Ligands for Opioid and CCK Receptors
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     Chapter 147 Antigen Effects of Peptide Nucleic Acids on HIF-1α Expression
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     Chapter 148 Novel Glyco-lipid-arsenicals (III) with Anti-proliferative Effects on MCF-7 Human Breast Cancer Cells
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     Chapter 149 Antisense PNA and PNA-peptide Conjugates for the Modulation of β-globin Gene Splicing
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     Chapter 150 β-Amino Acid Analogs of an Insect Neuropeptide
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     Chapter 151 Branched Neurotensin for Tumor Targeting
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     Chapter 152 CCK/MSH Analogs and Derivatives for Imaging and Incorporation in Multimeric Ligands
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     Chapter 153 Cellular Uptake of Pyrrolidine-Based Oxy-Peptide Nucleic Acid
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     Chapter 154 Chemical Biology and Biomedical Application of Synthetic Molecules Targeted to Apoptosis Regulated by the Bcl-2 Family
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     Chapter 155 Comparative Immunogenicity of Common and Rare HIV Mutant Peptides
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     Chapter 156 Conformational Studies of Agouti-Related Protein (AGRP)-Melanocortin Chimeric Peptides
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     Chapter 157 C-Terminal Ether Analogs of NN703
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     Chapter 158 Cyclic Statine-based Peptides as Inhibitors of β-Secretase
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     Chapter 159 Design and Structure Determination of a Selenium Labeled Antimicrobial Peptide
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     Chapter 160 Design and Synthesis of Encoded One-bead One-compound Peptidomimetic Libraries for Identification of α4β1 Integrin Ligands
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     Chapter 161 Design and Synthesis of Histone Deacetylase Inhibitors by Side Chain Modification of 2-Amino-(n-1)-alkenoic Acids
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     Chapter 162 Design of a Library of Histone Deacetylase Inhibitors Based on Chlamydocin
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     Chapter 163 Design of an Antibody for Early Detection of Ovarian Cancer
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     Chapter 164 Design, Synthesis and Applications of Cell-penetrant Peptides as Signal Transduction Modulators
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     Chapter 165 Novel MTII/AGRP Hybrid Analogs that Lead to Selective Ligands for the Human Melanocortin Receptors
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     Chapter 166 Design, Synthesis, and Evaluation of Gluten Peptide Analogs as Selective Inhibitors of Human TG2
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     Chapter 167 Novel Blue- and Red-Shifted Internally Quenched Fluorogenic Substrates for Continuous Monitoring of SARS-CoV 3CLpro
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     Chapter 168 Discovery and Optimization of a TRAIL R2 Agonist for Cancer Therapy
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     Chapter 169 Development of Peptide Vaccines against HPV-16 Associated Cervical Cancer and Group A Streptococci
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     Chapter 170 Disulfide as a Constraint to Build Super Potent and Selective Melanocortin-4 Receptor (MC4R) Agonists
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     Chapter 171 Effect of Dimerization and Tetramerization on the Potency of HIV-1 Integrase Inhibitory Peptides
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     Chapter 172 The Effects of Stable Bradykinin Receptor 2 Agonist B9972 on Pulmonary Vasculature in vitro and vivo
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     Chapter 173 Etk/Bmx Tyrosine Kinase Peptide Substrates and Inhibitors Derived from the Autophosphorylation Site of the Enzyme
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     Chapter 174 Fluorescence Resonance Energy Transfer Substrates for Determining Cathepsin B pH Specificity
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     Chapter 175 Ghrelin Attenuates Burn-induced Cachexia
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     Chapter 176 High Affinity High Specificity α4β1 Integrin Targeting Peptidomimetics for Lymphoid Cancers
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     Chapter 177 Highly N-Methylated Somatostatin Analogs: Synthesis, Biological Activity and Structure-Activity Relationship Studies
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     Chapter 178 Highly Sensitivity FRET Substrate for Assay of HCV Protease
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     Chapter 179 Identification and Characterization of Synthetic Peptide Substrates and Small Molecule Inhibitors of Non Receptor Tyrosine Kinase Etk
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     Chapter 180 Identification of High Affinity Anti-MCP-1 Antibodies using Synthetic Proteins
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     Chapter 181 Mapping Cell Binding using Collagen III “Toolkit”
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     Chapter 182 Modeling of α1 Adrenergic Receptors: the Application in the Design of Selective α1B-Adrenergic Antagonists
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     Chapter 183 Characterization of the Interaction of HIP Analog Peptide with Heparin
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     Chapter 184 New Urotensin-II Analogs Modified at Position 4
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     Chapter 185 New Urotensin-II Analogs with a Constrained Trp-7 Side Chain
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     Chapter 186 Novel GnRH Antagonists Derived from Degarelix: Exploration of the GnRH Antagonist Pharmacophore
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     Chapter 187 Novel Neuroprotective Neurotrophic NAP Analogs Targeting Iron Toxicity and Oxidative Stress in Neurodegenerative Diseases
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     Chapter 188 One-bead One-compound: Different Type of Screening Assays for Anti-bacterial Adhesion
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     Chapter 189 Peptide - Mediated Delivery of siRNA via Noncovalent Complexes and Covalent Conjugates
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     Chapter 190 Peptides Reproducing the ApoA-I 141–164 Region: Studies on Hpt Recognition
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     Chapter 191 Peptidomimetic Inhibitors of Platelet Adhesion as Potential Novel Antiplatelet Agents
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     Chapter 192 Peptidyl-based Delivery Systems as a Strategy for the Therapeutic Intervention of Human Astrocytoma and Medulloblastoma
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     Chapter 193 Photolabeling with N-Terminal Urotensin II Photoprobes Identifies Methionine 288 of Rat Urotensin Receptor as a Contact Point
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     Chapter 194 Protein Kinase C Isoform (PKC) Peptide Activator/Inhibitors Exert Cardioprotective Effects in Polymorphonuclear Leukocyte (PMN)-induced Ischemia/Reperfusion (I/R) Injury
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     Chapter 195 Rational Design of Small Molecules for a Novel Class of Anti-Cancer Drugs using a Phenylalanine Library
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     Chapter 196 Repair of Photodamaging Effects on Human Melanocytes by 4-Phenylbutryl-His-D-Phe-Arg-Trp-NH2. A Superpotent Analog of α-Melanocortin
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     Chapter 197 RGD Peptide-Labeled Quantum Dots for Integrin αvβ3 Targeting
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     Chapter 198 Rigid Cyclic Tetrapeptides as Probes and Mimics of Reverse Turns
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     Chapter 199 Solid-Phase Synthesis and Structure Characterization of N′-Biphenyl-N-2-Ethylbutyl-Demethylvancomycin
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     Chapter 200 Stereo-controlled Synthesis of [L-Arg, L/D-3-(2-Naphthyl)alanine]-type (E)-Alkene Dipeptide Isosteres and its Application to the Preparation and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
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     Chapter 201 Stochiometric Inhibition of β-Amyloid Fibrillogenesis using Cα,α-Disubstituted Amino Acid Containing Peptides
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     Chapter 202 Structure Determination of the Human Angiotensin II Receptor Type 1 by the Methionine Proximity Assay
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     Chapter 203 Structure-Activity Relationship Studies of a Novel CXCR4 Chemokine Antagonist Reveal Unique Activity Profile
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     Chapter 204 Studies on a Mutual Prodrug of Sulfamethoxazole and Nalidixic acid
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     Chapter 205 Studies on Interaction of CaM with CaM-Binding Peptides M13 and RS20 in the Presence of Al3+ Ions
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     Chapter 206 Studies on the Peroxidase Mimetic Peptide
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     Chapter 207 Use of Combinatorial Peptide Libraries and LC/MS/MS to Study TPP I Substrate Specificity
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     Chapter 208 Sunflower Derived Trypsin Inhibitors as Anti-Metastatics
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     Chapter 209 Surface Plasmon Resonance- and Quartz Crystal Microbalance-based Methods for Detecting GRB2 SH2 / Peptide Interaction
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     Chapter 210 Synthesis and Biological Activity of Terlipressin and its Putative Metabolites
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     Chapter 211 Synthesis and Evaluation of Neuroprotective α,β-Unsaturated Aldehyde Scavenger Histidyl-containing Analogs of Carnosine
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     Chapter 212 Synthesis, Structural Characterization and Reactivity Study of Humanin, an Alzheimer’s Disease Associated Peptide
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     Chapter 213 Synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones and Study of their β-turn Inducing Properties
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     Chapter 214 Synthesis of a RGD Peptide-PEG Hybrid for Carrying Adenovirus Vector into Cells
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     Chapter 215 Synthesis of Cyclic Imino Acids from α-Amino-ω-Bromoalkanoic Acids
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     Chapter 216 Synthesis of Quantum Dots Labeled Short Peptides and their Application in Imaging the T Cell Surface Receptors
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     Chapter 217 Synthesis of Quantum Dot-Signal Peptides Bioconjugates and Targeting in Living Cells
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     Chapter 218 Synthesis of Symmetrical Dimeric Dicarboxylic Acid Linked Peptides on Solid Support
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     Chapter 219 Systematic Study on the Structure-Activity Relationship of Pyrazinone Ring-Containing Bioactive Opioid Ligands
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     Chapter 220 Tetra and Pentapeptide Derivatives of Hemiasterlin. Synthesis and Activity Studies
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     Chapter 221 The Chemo-enzymatic Synthesis of Oligosaccharide-linked Peptides Aimed at Improved Drug Delivery
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     Chapter 222 Neokyotorphin as Cell Protein Kinase Affector
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     Chapter 223 Towards Inhibition of Amyloid β-protein Oligomerization
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     Chapter 224 Use of Betidamino Acids in Drug Design
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     Chapter 225 Helical Peptide Analogs of gp41 to Develop an HIV Vaccine
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     Chapter 226 Structure-Activity Relationship Studies of a Novel AGRP-Melanocortin Chimeric Template
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     Chapter 227 Synthesis and Pharmacological Evaluation of a New Generation of TIPP-Derived Dual-Labeled Ligands for Delta Opioid Receptors
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     Chapter 228 Synthesis and Pharmacological Evaluation of Dual Labeled Delta Opioid Receptor Peptides
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     Chapter 229 Novel Retro-inverso Envelope Peptide Mimetic Fusion Inhibitors as a Potential Therapy for HTLV-1 Infected Individuals
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     Chapter 230 Heteroclitic Analogs Derived from the HTLV-1 Gag Antigen Increase Cytolytic and IFN-γ Responses in HLA-A*0201 Transgenic Mice
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     Chapter 231 Development of a Monoclonal Antibody Therapeutic for the Prevention and Treatment of Pseudomonas aeruginosa Infection
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     Chapter 232 An Unexpected Side Reaction Involving the Deletion of an Acetylated N-Methyl-Amino Acid from the N-terminus of Peptides
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     Chapter 233 Synthesis and Biological Activities of Chimeric Bioactive Peptides Based on Amino Acids Coupled to 4-Anilino-N-Phenethyl-Piperidine
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     Chapter 234 Discovery of Potent mMC1R Agonists with Prolonged Activity at Human Melanocytes
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     Chapter 235 β-Hairpin Minimization and Optimization
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     Chapter 236 Analogs of Interleukin 8 Containing non Proteinogenic Segments Show High Biological Activity
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     Chapter 237 Optimization of the C-terminal Sequence in Glucagon to Maximize Receptor Affinity
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     Chapter 238 Design, Synthesis, and Evaluation of Piperazine-Based Small Molecule Peptide Mimetics Targeting the Melanocortin Receptors
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     Chapter 239 Structure-Based Design and Structure-Activity Relationships of D-Phe-Pro-D-Arg-P1′-CONH2 Tetrapeptides Inhibitors of Thrombin
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     Chapter 240 A Gibberellin Mimetic Peptide Recognized by an Anti-gibberellin Monoclonal Antibody
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     Chapter 241 Synthesis of the Spin-labelled β-Amino Acids cis- and trans-β-TOAC, and a Preliminary Conformational Study of trans-β-TOAC/trans-ACHC Peptides
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     Chapter 242 High Affinity Grb2 SH2 Domain-Binding Macrocycles Derived from Ring-Closing Methathesis of Alkenylglyicne Residues with β-Vinyl Phosphotyrosyl Mimetics
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     Chapter 243 Towards Photo-Controlled Collagens
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     Chapter 244 Template-Assembled Peptide Models of the N-Peptide Helix Bundle from HIV-1 gp41
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     Chapter 245 Alignment of Three Nitroxide Radicals on the Same Face of a Helical Peptide Scaffold
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     Chapter 246 Design, Synthesis, and Preferred Conformation of Peptides Based on a Highly Constrained, β,β′-Diphenyl Substituted Cyclopropane α-Amino Acid
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     Chapter 247 Identification of a Novel HIV-1 Neutralizing Antibody Using Synthetic Peptides that Mimic a GP41 Fusion Intermediate
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     Chapter 248 Covalent Trimeric Coiled Coils of the HIV gp41 HR1 Region are Extremely Potent and Broadly Neutralizing Inhibitors of Viral Infection
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     Chapter 249 Selective Agonists for the Human Vasopressin V1b Receptor are Potent Antidiuretic Agonists in the Rat
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     Chapter 250 Prion Protein Misfolding: Conformational Stability of the α2-Helix
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     Chapter 251 Modeling Flexible Loops in the Dark-Adapted and Activated States of Rhodopsin, a Prototypical G-protein-Coupled Receptor
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     Chapter 252 Deducing 3D Models of the Activated States for TM Regions of GPCRs by Modeling Constitutively Active Mutants: The Test Case of Opsin
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     Chapter 253 Identification of a Unique Stability Propagation Site that Controls Protein Stability of α-Tropomyosin: a Two-Stranded α-Helical Coiled-coil
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     Chapter 254 The Introduction of Uncharged α-Hydroxymethyl Amino Acid Residues in Substrate Specificity P1 Position of Trypsin Inhibitor SFTI-1 from Sunflower Seeds Retains its Activity
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     Chapter 255 Molecular Simulation of an α/ɛ-Peptide Dendrimer
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     Chapter 320 The Tertiary Structure of Aβ1-40 Determined by Scanning Tunnelling Microscopy