Title |
Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children
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Published in |
Journal of Autism and Developmental Disorders, April 2017
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DOI | 10.1007/s10803-017-3130-4 |
Pubmed ID | |
Authors |
Stacey E. Alexeeff, Vincent Yau, Yinge Qian, Meghan Davignon, Frances Lynch, Phillip Crawford, Robert Davis, Lisa A. Croen |
Abstract |
This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0-23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1-3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification. Our findings provide new evidence indicating that children with ASD have a disproportionate burden of certain medical conditions preceding ASD diagnosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 18% |
United Kingdom | 5 | 15% |
Spain | 4 | 12% |
Australia | 2 | 6% |
Venezuela, Bolivarian Republic of | 2 | 6% |
Canada | 2 | 6% |
Chile | 1 | 3% |
Mexico | 1 | 3% |
Unknown | 11 | 32% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 26 | 76% |
Practitioners (doctors, other healthcare professionals) | 5 | 15% |
Scientists | 3 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Unknown | 160 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 29 | 18% |
Student > Ph. D. Student | 25 | 16% |
Researcher | 15 | 9% |
Student > Bachelor | 15 | 9% |
Student > Doctoral Student | 8 | 5% |
Other | 23 | 14% |
Unknown | 46 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 22 | 14% |
Medicine and Dentistry | 20 | 12% |
Nursing and Health Professions | 13 | 8% |
Neuroscience | 12 | 7% |
Social Sciences | 8 | 5% |
Other | 29 | 18% |
Unknown | 57 | 35% |