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Carbonic anhydrase activity of dinuclear Cu II complexes with patellamide model ligands

Overview of attention for article published in Dalton Transactions: An International Journal of Inorganic Chemistry, January 2014
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Title
Carbonic anhydrase activity of dinuclear Cu II complexes with patellamide model ligands
Published in
Dalton Transactions: An International Journal of Inorganic Chemistry, January 2014
DOI 10.1039/c3dt53135j
Pubmed ID
Authors

Peter Comba, Lawrence R. Gahan, Graeme R. Hanson, Marcel Maeder, Michael Westphal

Abstract

The dicopper(II) complexes of six pseudo-octapeptides, synthetic analogues of ascidiacyclamide and the patellamides, found in ascidians of the Pacific and Indian Oceans, are shown to be efficient carbonic anhydrase model complexes with k(cat) up to 7.3 × 10(3) s(-1) (uncatalyzed: 3.7 × 10(-2) s(-1); enzyme-catalyzed: 2 × 10(5)-1.4 × 10(6) s(-1)) and a turnover number (TON) of at least 1700, limited only by the experimental conditions used. So far, no copper-based natural carbonic anhydrases are known, no faster model systems have been described and the biological role of the patellamide macrocycles is so far unknown. The observed CO2 hydration rates depend on the configuration of the isopropyl side chains of the pseudo-octapeptide scaffold, and the naturally observed R*,S*,R*,S* geometry is shown to lead to more efficient catalysts than the S*,S*,S*,S* isomers. The catalytic efficiency also depends on the heterocyclic donor groups of the pseudo-octapeptides. Interestingly, the dicopper(II) complex of the ligand with four imidazole groups is a more efficient catalyst than that of the close analogue of ascidiacyclamide with two thiazole and two oxazoline rings. The experimental observations indicate that the nucleophilic attack of a Cu(II)-coordinated hydroxide at the CO2 carbon center is rate determining, i.e. formation of the catalyst-CO2 adduct and release of carbonate/bicarbonate are relatively fast processes.

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Mendeley readers

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The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 16%
Student > Bachelor 3 16%
Student > Ph. D. Student 3 16%
Professor 3 16%
Student > Doctoral Student 2 11%
Other 2 11%
Unknown 3 16%
Readers by discipline Count As %
Chemistry 12 63%
Biochemistry, Genetics and Molecular Biology 1 5%
Physics and Astronomy 1 5%
Agricultural and Biological Sciences 1 5%
Unknown 4 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2014.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Dalton Transactions: An International Journal of Inorganic Chemistry
#10,056
of 21,061 outputs
Outputs of similar age
#233,955
of 319,280 outputs
Outputs of similar age from Dalton Transactions: An International Journal of Inorganic Chemistry
#544
of 1,585 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 21,061 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,585 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.