| Title |
Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction
|
|---|---|
| Published in |
Brain Imaging and Behavior, November 2013
|
| DOI | 10.1007/s11682-013-9272-x |
| Pubmed ID | |
| Authors |
Leo Ungar, Andre Altmann, Michael D. Greicius |
| Abstract |
Alzheimer's disease (AD) is an increasingly prevalent, fatal neurodegenerative disease that has proven resistant, thus far, to all attempts to prevent it, forestall it, or slow its progression. The ε4 allele of the Apolipoprotein E gene (APOE4) is a potent genetic risk factor for sporadic and late-onset familial AD. While the link between APOE4 and AD is strong, many expected effects, like increasing the risk of conversion from MCI to AD, have not been widely replicable. One critical, and commonly overlooked, feature of the APOE4 link to AD is that several lines of evidence suggest it is far more pronounced in women than in men. Here we review previous literature on the APOE4 by gender interaction with a particular focus on imaging-related studies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | <1% |
| Germany | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Austria | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 196 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 19% |
| Researcher | 31 | 15% |
| Student > Master | 31 | 15% |
| Student > Bachelor | 18 | 9% |
| Student > Doctoral Student | 12 | 6% |
| Other | 30 | 15% |
| Unknown | 41 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 33 | 16% |
| Psychology | 24 | 12% |
| Agricultural and Biological Sciences | 23 | 11% |
| Medicine and Dentistry | 19 | 9% |
| Biochemistry, Genetics and Molecular Biology | 13 | 6% |
| Other | 33 | 16% |
| Unknown | 57 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2022.
All research outputs
#1,331,761
of 23,575,346 outputs
Outputs from Brain Imaging and Behavior
#66
of 1,164 outputs
Outputs of similar age
#15,463
of 310,008 outputs
Outputs of similar age from Brain Imaging and Behavior
#4
of 25 outputs
Altmetric has tracked 23,575,346 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,164 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,008 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.