| Title |
Diabetes, bone and glucose-lowering agents: basic biology
|
|---|---|
| Published in |
Diabetologia, April 2017
|
| DOI | 10.1007/s00125-017-4269-4 |
| Pubmed ID | |
| Authors |
Beata Lecka-Czernik |
| Abstract |
Skeletal fragility often accompanies diabetes and does not appear to correlate with low bone mass or trauma severity in individuals with diabetes. Instead (and in contrast to those with osteoporotic bone disease), bone remodelling and bone turnover are compromised in both type 1 and type 2 diabetes, contributing to defective bone material quality. This review is one of a pair discussing the relationship between diabetes, bone and glucose-lowering agents; an accompanying review is provided in this issue of Diabetologia by Ann Schwartz (DOI: 10.1007/s00125-017-4283-6 ). This review presents basic science evidence that, alongside other organs, bone is affected in diabetes via impairments in glucose metabolism, toxic effects of glucose oxidative derivatives (advance glycation end-products [AGEs]), and via impairments in bone microvascular function and muscle endocrine function. The cellular and molecular basis for the effects of diabetes on bone are discussed, as is the impact of diabetes on the stem cell niche and fracture healing. Furthermore, the safety of clinically approved glucose-lowering therapies and the possibility of developing a single therapy that would be beneficial for both insulin sensitisation and diabetes bone syndrome are outlined. |
X Demographics
The data shown below were collected from the profiles of 65 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 7 | 11% |
| Spain | 7 | 11% |
| United Kingdom | 5 | 8% |
| United States | 4 | 6% |
| Denmark | 3 | 5% |
| Peru | 2 | 3% |
| Philippines | 1 | 2% |
| Dominican Republic | 1 | 2% |
| Germany | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 29 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 47 | 72% |
| Practitioners (doctors, other healthcare professionals) | 11 | 17% |
| Scientists | 6 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 140 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 13% |
| Student > Bachelor | 15 | 11% |
| Student > Master | 13 | 9% |
| Researcher | 10 | 7% |
| Other | 9 | 6% |
| Other | 26 | 18% |
| Unknown | 51 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 34% |
| Biochemistry, Genetics and Molecular Biology | 12 | 8% |
| Agricultural and Biological Sciences | 5 | 4% |
| Nursing and Health Professions | 3 | 2% |
| Engineering | 3 | 2% |
| Other | 16 | 11% |
| Unknown | 55 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2020.
All research outputs
#1,125,349
of 25,223,158 outputs
Outputs from Diabetologia
#605
of 5,331 outputs
Outputs of similar age
#22,207
of 315,663 outputs
Outputs of similar age from Diabetologia
#14
of 77 outputs
Altmetric has tracked 25,223,158 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,331 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.