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Arrestins - Pharmacology and Therapeutic Potential

Overview of attention for book
Cover of 'Arrestins - Pharmacology and Therapeutic Potential'

Table of Contents

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    Book Overview
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    Chapter 1 Therapeutic Potential of Small Molecules and Engineered Proteins
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    Chapter 2 Arrestin interactions with g protein-coupled receptors.
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    Chapter 3 Quantifying Biased β-Arrestin Signaling
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    Chapter 4 The Physiological Roles of Arrestin-1 in Rod Photoreceptor Cells
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    Chapter 5 Not Just Signal Shutoff: The Protective Role of Arrestin-1 in Rod Cells
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    Chapter 6 Cone Arrestin: Deciphering the Structure and Functions of Arrestin 4 in Vision
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    Chapter 7 Enhanced Phosphorylation-Independent Arrestins and Gene Therapy
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    Chapter 8 Targeting Individual GPCRs with Redesigned Nonvisual Arrestins
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    Chapter 9 β-Arrestins and G Protein-Coupled Receptor Trafficking.
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    Chapter 10 Arrestin interaction with e3 ubiquitin ligases and deubiquitinases: functional and therapeutic implications.
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    Chapter 11 Self-Association of Arrestin Family Members
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    Chapter 12 Arrestin-Dependent Activation of ERK and Src Family Kinases
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    Chapter 13 Arrestin-Dependent Activation of JNK Family Kinases
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    Chapter 14 Arrestin-Mediated Activation of p38 MAPK: Molecular Mechanisms and Behavioral Consequences
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    Chapter 15 Arrestin-dependent localization of phosphodiesterases.
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    Chapter 16 Arrestins in Apoptosis
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    Chapter 17 Molecular Mechanisms Underlying Beta-Arrestin-Dependent Chemotaxis and Actin-Cytoskeletal Reorganization
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    Chapter 18 Arrestins in Host–Pathogen Interactions
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    Chapter 19 Arrestin Regulation of Small GTPases
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    Chapter 20 GPCRs and Arrestins in Airways: Implications for Asthma
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    Chapter 21 Arrestins as Regulatory Hubs in Cancer Signalling Pathways
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    Chapter 22 β-Arrestins: Regulatory Role and Therapeutic Potential in Opioid and Cannabinoid Receptor-Mediated Analgesia.
Attention for Chapter 9: β-Arrestins and G Protein-Coupled Receptor Trafficking.
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Citations

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Chapter title
β-Arrestins and G Protein-Coupled Receptor Trafficking.
Chapter number 9
Book title
Arrestins - Pharmacology and Therapeutic Potential
Published in
Handbook of experimental pharmacology, January 2014
DOI 10.1007/978-3-642-41199-1_9
Pubmed ID
24292830
Book ISBNs
978-3-64-241198-4, 978-3-64-241199-1
Authors

Xufan Tian, Dong Soo Kang, Jeffrey L Benovic, Jeffrey L. Benovic, Tian, Xufan, Kang, Dong Soo, Benovic, Jeffrey L.

Abstract

Nonvisual arrestins (β-arrestin-1 and β-arrestin-2) are adaptor proteins that function to regulate G protein-coupled receptor (GPCR) signaling and trafficking. β-arrestins are ubiquitously expressed and function to inhibit GPCR/G protein coupling, a process called desensitization, and promote GPCR trafficking and arrestin-mediated signaling. β-arrestin-mediated endocytosis of GPCRs requires the coordinated interaction of β-arrestins with clathrin, adaptor protein 2 (AP2), and phosphoinositides. These interactions are facilitated by a conformational change in β-arrestin that is thought to occur upon binding to a phosphorylated activated GPCR. In this review, we provide an overview of the key interactions involved in β-arrestin-mediated trafficking of GPCRs.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 168 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 26%
Student > Master 25 15%
Student > Bachelor 17 10%
Researcher 12 7%
Student > Doctoral Student 10 6%
Other 15 9%
Unknown 46 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 40 24%
Agricultural and Biological Sciences 25 15%
Pharmacology, Toxicology and Pharmaceutical Science 22 13%
Medicine and Dentistry 9 5%
Chemistry 7 4%
Other 15 9%
Unknown 50 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2013.
All research outputs
#18,811,512
of 23,313,051 outputs
Outputs from Handbook of experimental pharmacology
#509
of 650 outputs
Outputs of similar age
#232,265
of 308,001 outputs
Outputs of similar age from Handbook of experimental pharmacology
#19
of 24 outputs
Altmetric has tracked 23,313,051 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 650 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,001 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.

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