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Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

Overview of attention for article published in Journal of Cell Science, November 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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4 patents
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1 Facebook page

Citations

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148 Dimensions

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203 Mendeley
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Title
Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies
Published in
Journal of Cell Science, November 2013
DOI 10.1242/jcs.114041
Pubmed ID
Authors

Marco Sandri, Luisa Coletto, Paolo Grumati, Paolo Bonaldo

Abstract

A number of recent studies have highlighted the importance of autophagy and the ubiquitin-proteasome in the pathogenesis of muscle wasting in different types of inherited muscle disorders. Autophagy is crucial for the removal of dysfunctional organelles and protein aggregates, whereas the ubiquitin-proteasome is important for the quality control of proteins. Post-mitotic tissues, such as skeletal muscle, are particularly susceptible to aged or dysfunctional organelles and aggregation-prone proteins. Therefore, these degradation systems need to be carefully regulated in muscles. Indeed, excessive or defective activity of the autophagy lysosome or ubiquitin-proteasome leads to detrimental effects on muscle homeostasis. A growing number of studies link abnormalities in the regulation of these two pathways to myofiber degeneration and muscle weakness. Understanding the pathogenic role of these degradative systems in each inherited muscle disorder might provide novel therapeutic targets to counteract muscle wasting. In this Commentary, we will discuss the current view on the role of autophagy lysosome and ubiquitin-proteasome in the pathogenesis of myopathies and muscular dystrophies, and how alteration of these degradative systems contribute to muscle wasting in inherited muscle disorders. We will also discuss how modulating autophagy and proteasome might represent a promising strategy for counteracting muscle loss in different diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Turkey 1 <1%
Italy 1 <1%
Netherlands 1 <1%
Spain 1 <1%
Brazil 1 <1%
Unknown 196 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 54 27%
Researcher 34 17%
Student > Master 31 15%
Student > Bachelor 18 9%
Student > Doctoral Student 11 5%
Other 22 11%
Unknown 33 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 60 30%
Biochemistry, Genetics and Molecular Biology 56 28%
Medicine and Dentistry 25 12%
Sports and Recreations 7 3%
Neuroscience 4 2%
Other 12 6%
Unknown 39 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2022.
All research outputs
#3,770,739
of 25,374,647 outputs
Outputs from Journal of Cell Science
#1,010
of 9,020 outputs
Outputs of similar age
#42,080
of 320,855 outputs
Outputs of similar age from Journal of Cell Science
#22
of 286 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,020 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,855 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 286 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.