Title |
Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report
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Published in |
BMC Neurology, April 2017
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DOI | 10.1186/s12883-017-0858-6 |
Pubmed ID | |
Authors |
Yoshitsugu Nakamura, Hideto Nakajima, Hiroki Tani, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Kimihiko Kaneko, Toshiyuki Takahashi, Ichiro Nakashima |
Abstract |
Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection. A 36-year-old healthy man developed paresthesia of bilateral lower extremities and urinary retention 8 days after the onset of IM due to primary EBV infection. The MRI revealed the lesions in the cervical spinal cord, the conus medullaris, and the internal capsule. An examination of the cerebrospinal fluid revealed pleocytosis. Cell-based immunoassays revealed positivity for anti-MOG antibody with a titer of 1:1024 and negativity for anti-aquaporin-4 antibody. His symptoms quickly improved after steroid pulse therapy followed by oral betamethasone. Anti-MOG antibody titer at the 6-month follow-up was negative. This case suggests that primary EBV infection would trigger anti-MOG antibody-positive ADEM. Adult ADEM patients can be positive for anti-MOG antibody, the titers of which correlate well with the neurological symptoms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 11 | 16% |
Student > Postgraduate | 8 | 12% |
Student > Doctoral Student | 7 | 10% |
Researcher | 6 | 9% |
Student > Bachelor | 4 | 6% |
Other | 16 | 24% |
Unknown | 16 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 36 | 53% |
Agricultural and Biological Sciences | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Neuroscience | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 4 | 6% |
Unknown | 20 | 29% |