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The Relative Effect of Sterols and Hopanoids on Lipid Bilayers: When Comparable Is Not Identical

Overview of attention for article published in Journal of Physical Chemistry B, December 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

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1 blog
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1 X user
wikipedia
2 Wikipedia pages

Citations

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43 Dimensions

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76 Mendeley
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Title
The Relative Effect of Sterols and Hopanoids on Lipid Bilayers: When Comparable Is Not Identical
Published in
Journal of Physical Chemistry B, December 2013
DOI 10.1021/jp409748d
Pubmed ID
Authors

David Poger, Alan E. Mark

Abstract

Sterols are the hallmarks of eukaryotic membranes where they are often found in specialized functional microdomains of the plasma membrane called lipid rafts. Despite some notable exceptions, prokaryotes lack sterols. However, growing evidence has suggested the existence of raft-like domains in the plasma membrane of bacteria. A structurally related family of triterpenoids found in some bacteria called hopanoids has long been assumed to be bacterial surrogates for sterols in membranes. Although the effect of sterols, in particular cholesterol, on lipid bilayers has been extensively characterized through experimental and simulation studies, those of hopanoids have hardly been investigated. In this study, molecular dynamics simulations are used to examine the effect of two hopanoids, diploptene (hop-22(29)-ene) and bacteriohopanetetrol ((32R,33S,34S)-bacteriohopane-32,33,34,35-tetrol), on a model bilayer. The results are compared with those obtained for cholesterol and a pure phosphatidylcholine bilayer. It is shown that diploptene and bacteriohopanetetrol behave very differently under the conditions simulated. Whereas bacteriohopanetetrol adopted a cholesterol-like upright orientation in the bilayer, diploptene partitioned between the two leaflets inside the bilayer. Analysis of various structural properties (area per lipid, electron density profile, tilt angle of the lipids, and conformation and order parameters of the phosphatidylcholine tails) in bacteriohopanetetrol- and cholesterol-containing bilayers indicates that the condensing and ordering effect of bacteriohopanetetrol is weaker than that of cholesterol. The simulations suggest that the chemical diversity of hopanoids may lead to a broader range of functional roles in bacterial membranes than sterols in eukaryotic membranes.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Japan 1 1%
Unknown 73 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 24%
Student > Master 14 18%
Researcher 13 17%
Student > Bachelor 6 8%
Professor > Associate Professor 5 7%
Other 8 11%
Unknown 12 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 18%
Agricultural and Biological Sciences 14 18%
Chemistry 13 17%
Earth and Planetary Sciences 5 7%
Physics and Astronomy 3 4%
Other 10 13%
Unknown 17 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2020.
All research outputs
#2,806,036
of 25,377,790 outputs
Outputs from Journal of Physical Chemistry B
#275
of 14,908 outputs
Outputs of similar age
#31,144
of 320,279 outputs
Outputs of similar age from Journal of Physical Chemistry B
#2
of 176 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,908 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,279 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.