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A prion protein variant in a family with the telencephalic form of Gerstmann-Sträussler-Scheinker syndrome.

Overview of attention for article published in Neurology, May 1991
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

blogs
1 blog
patent
15 patents

Citations

dimensions_citation
148 Dimensions

Readers on

mendeley
50 Mendeley
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Title
A prion protein variant in a family with the telencephalic form of Gerstmann-Sträussler-Scheinker syndrome.
Published in
Neurology, May 1991
DOI 10.1212/wnl.41.5.681
Pubmed ID
Authors

K K Hsiao, C Cass, G D Schellenberg, T Bird, E Devine-Gage, H Wisniewski, S B Prusiner

Abstract

We present a patient with a mutation in the open reading frame of the prion protein gene (PRNP), which results in substitution of valine for alanine at codon 117. The patient is a member of a large American kindred of German descent with the telencephalic form of Gerstmann-Sträussler-Scheinker syndrome (GSS). Two other affected members of this kindred carried this mutation, as inferred from haplotypes of their offspring and spouses. The mutation was absent in one member with a protracted neurologic illness that differed from the other affected members' illnesses. The identification of a distinct PRNP mutation in the telencephalic form of GSS supports the hypothesis that allelic forms of PRNP may correspond to distinct clinical disease entities.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 28%
Professor 7 14%
Student > Ph. D. Student 6 12%
Student > Doctoral Student 4 8%
Student > Bachelor 2 4%
Other 8 16%
Unknown 9 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 24%
Agricultural and Biological Sciences 9 18%
Medicine and Dentistry 6 12%
Neuroscience 5 10%
Psychology 2 4%
Other 6 12%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2017.
All research outputs
#3,817,356
of 22,965,074 outputs
Outputs from Neurology
#6,675
of 20,001 outputs
Outputs of similar age
#1,773
of 17,779 outputs
Outputs of similar age from Neurology
#7
of 29 outputs
Altmetric has tracked 22,965,074 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 20,001 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 17,779 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.