| Title |
The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds
|
|---|---|
| Published in |
Journal of the Association for Research in Otolaryngology, April 2017
|
| DOI | 10.1007/s10162-017-0622-z |
| Pubmed ID | |
| Authors |
Ana Diaz-Artiles, Adrian J. Priesol, Torin K. Clark, David P. Sherwood, Charles M. Oman, Laurence R. Young, Faisal Karmali |
| Abstract |
Despite the widespread treatment of motion sickness symptoms using drugs and the involvement of the vestibular system in motion sickness, little is known about the effects of anti-motion sickness drugs on vestibular perception. In particular, the impact of oral promethazine, widely used for treating motion sickness, on vestibular perceptual thresholds has not previously been quantified. We examined whether promethazine (25 mg) alters vestibular perceptual thresholds in a counterbalanced, double-blind, within-subject study. Thresholds were determined using a direction recognition task (left vs. right) for whole-body yaw rotation, y-translation (interaural), and roll tilt passive, self-motions. Roll tilt thresholds were 31 % higher after ingestion of promethazine (P = 0.005). There were no statistically significant changes in yaw rotation and y-translation thresholds. This worsening of precision could have functional implications, e.g., during driving, bicycling, and piloting tasks. Differing results from some past studies of promethazine on the vestibulo-ocular reflex emphasize the need to study motion perception in addition to motor responses. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 21% |
| Researcher | 6 | 18% |
| Student > Doctoral Student | 5 | 15% |
| Student > Master | 3 | 9% |
| Student > Bachelor | 2 | 6% |
| Other | 6 | 18% |
| Unknown | 4 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 30% |
| Engineering | 6 | 18% |
| Nursing and Health Professions | 3 | 9% |
| Psychology | 3 | 9% |
| Unspecified | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 7 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2020.
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#642,535
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Outputs from Journal of the Association for Research in Otolaryngology
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#14,157
of 311,568 outputs
Outputs of similar age from Journal of the Association for Research in Otolaryngology
#1
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So far Altmetric has tracked 429 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 98% of its peers.
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