Title |
An exact approach for studying cargo transport by an ensemble of molecular motors
|
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Published in |
BMC Biophysics, November 2013
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DOI | 10.1186/2046-1682-6-14 |
Pubmed ID | |
Authors |
Donatello Materassi, Subhrajit Roychowdhury, Thomas Hays, Murti Salapaka |
Abstract |
Intracellular transport is crucial for many cellular processes where a large fraction of the cargo is transferred by motor-proteins over a network of microtubules. Malfunctions in the transport mechanism underlie a number of medical maladies.Existing methods for studying how motor-proteins coordinate the transfer of a shared cargo over a microtubule are either analytical or are based on Monte-Carlo simulations. Approaches that yield analytical results, while providing unique insights into transport mechanism, make simplifying assumptions, where a detailed characterization of important transport modalities is difficult to reach. On the other hand, Monte-Carlo based simulations can incorporate detailed characteristics of the transport mechanism; however, the quality of the results depend on the number and quality of simulation runs used in arriving at results. Here, for example, it is difficult to simulate and study rare-events that can trigger abnormalities in transport. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 6% |
Unknown | 15 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 25% |
Researcher | 3 | 19% |
Student > Doctoral Student | 2 | 13% |
Student > Postgraduate | 2 | 13% |
Professor | 1 | 6% |
Other | 3 | 19% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
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Engineering | 4 | 25% |
Neuroscience | 3 | 19% |
Agricultural and Biological Sciences | 2 | 13% |
Social Sciences | 2 | 13% |
Physics and Astronomy | 1 | 6% |
Other | 3 | 19% |
Unknown | 1 | 6% |