| Title |
The Spatio-Temporal Expression Profiles of CD4 + T Cell Differentiation and Function-Related Genes During EAE Pathogenesis
|
|---|---|
| Published in |
Inflammation, November 2016
|
| DOI | 10.1007/s10753-016-0469-1 |
| Pubmed ID | |
| Authors |
Yingying Cai, Hu Shen, Chaoyan Qin, Jinfeng Zhou, Weiming Lai, Juping Pan, Changsheng Du |
| Abstract |
Multiple sclerosis is a CD4(+) T cell-mediated autoimmune disease of the central nervous system. The unbalance of the cytokines and transcription factors critical for CD4(+) T cell differentiation and function is probably the main reason that causes MS. We detected the mRNA expression changes of key cytokines and transcription factors which are critical for Th1, Th2, Th17, and Treg cell differentiation and function in different tissues during EAE pathogenesis. We fund that each gene not only has its own featured expression changes, but also has interaction with one another, which composes a network of immunity. Understanding the roles of key cytokines and transcription factors in these processes will help to understand disease pathogenesis and supply indications for disease therapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 5% |
| Unknown | 21 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 18% |
| Student > Doctoral Student | 3 | 14% |
| Researcher | 3 | 14% |
| Student > Master | 3 | 14% |
| Professor > Associate Professor | 2 | 9% |
| Other | 4 | 18% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 18% |
| Immunology and Microbiology | 3 | 14% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Agricultural and Biological Sciences | 2 | 9% |
| Psychology | 2 | 9% |
| Other | 5 | 23% |
| Unknown | 4 | 18% |
Attention Score in Context
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#20,414,746
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Outputs from Inflammation
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#349,749
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Outputs of similar age from Inflammation
#10
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