Title |
Measuring telomere length for the early detection of precursor lesions of esophageal squamous cell carcinoma
|
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Published in |
BMC Cancer, December 2013
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DOI | 10.1186/1471-2407-13-578 |
Pubmed ID | |
Authors |
Shih-Wen Lin, Christian C Abnet, Neal D Freedman, Gwen Murphy, Rosana Risques, Donna Prunkard, Peter Rabinovitch, Qin-Jing Pan, Mark J Roth, Guo-Qing Wang, Wen-Qiang Wei, Ning Lu, Philip R Taylor, You-Lin Qiao, Sanford M Dawsey |
Abstract |
Esophageal cancer is the sixth leading cause of cancer death worldwide; current early detection screening tests are inadequate. Esophageal balloon cytology successfully retrieves exfoliated and scraped superficial esophageal epithelial cells, but cytologic reading of these cells has poor sensitivity and specificity for detecting esophageal squamous dysplasia (ESD), the precursor lesion of esophageal squamous cell carcinoma (ESCC). Measuring telomere length, a marker for chromosomal instability, may improve the utility of balloon cytology for detecting ESD and early ESCC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 28% |
Student > Master | 6 | 21% |
Student > Bachelor | 2 | 7% |
Researcher | 2 | 7% |
Professor | 2 | 7% |
Other | 3 | 10% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 45% |
Agricultural and Biological Sciences | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Nursing and Health Professions | 1 | 3% |
Other | 1 | 3% |
Unknown | 7 | 24% |