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The lethal action of 2-phenoxyethanol and its analogues upon Escherichia coli NCTC 5933.

Overview of attention for article published in Microbios, January 1977
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Citations

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Title
The lethal action of 2-phenoxyethanol and its analogues upon Escherichia coli NCTC 5933.
Published in
Microbios, January 1977
Pubmed ID
Authors

P Gilbert, E G Beveridge, P B Crone

Abstract

Bactericidal activity has been assessed for a number of glycolmonophenyl ethers towards Escherichia coli NCTC 5933, and the action of one analogue, 2-phenoxyethanol, has been studied in greater detail. For this compound the onset of bactericidal activity towards Escherichia coli occurred at concentrations which also induced considerable increases in drug uptake, marked leakage of cytoplasmic constituents, the cellular penetration of N-tolyl-alpha-napthylamine-8-sulphonic acid, and morphological changes consistent with gross membrane damage. However, temperature coefficients of rates of cellular leakage of low molecular weight cytoplasmic constituents, and rates of kill, were markedly different and suggested that the two phenomena were not integrally related, but that each was a consequence of some other action of the drug. Drug levels considerably below those possessing lethal activity, however, promoted the ready efflux of potassium ions from cells and caused disorganisation of the outer lipopolysaccharide-rich regions of the cell envelope.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 40%
Unspecified 1 20%
Other 1 20%
Student > Bachelor 1 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 40%
Unspecified 1 20%
Engineering 1 20%
Unknown 1 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2019.
All research outputs
#14,931,166
of 22,965,074 outputs
Outputs from Microbios
#18
of 39 outputs
Outputs of similar age
#15,746
of 23,220 outputs
Outputs of similar age from Microbios
#2
of 4 outputs
Altmetric has tracked 22,965,074 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 39 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one scored the same or higher as 21 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 23,220 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.