Title |
Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection
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Published in |
PLOS ONE, November 2013
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DOI | 10.1371/journal.pone.0080172 |
Pubmed ID | |
Authors |
Magdalena Ydreborg, Johan Westin, Karolina Rembeck, Magnus Lindh, Hans Norrgren, Anna Holmberg, Rune Wejstål, Gunnar Norkrans, Kristina Cardell, Ola Weiland, Martin Lagging |
Abstract |
Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of hepatitis C virus (HCV) infection as well as outcome following pegylated interferon and ribavirin therapy among genotype 1 infected patients. Additionally the presence of the otherwise favorable IL28B genetic variants in the context of HCV genotype 3 infection reportedly entail more pronounced liver fibrosis and steatosis. The present study aimed to evaluate the impact of IL28B SNP variability on liver stiffness as accessed by transient elastography. |
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