Title |
A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt(II), Zn(II), Cu(II), and Co(III) Complexes with N‐heteroaromatic Schiff Base (E)‐2‐[N′‐(1‐pyridin‐2‐yl‐ethylidene)hydrazino]acetate
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Published in |
Journal of Biochemical & Molecular Toxicology, December 2013
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DOI | 10.1002/jbt.21541 |
Pubmed ID | |
Authors |
Nenad R. Filipović, Ivanka Marković, Dragana Mitić, Natalija Polović, Miloš Milčić, Marija Dulović, Maja Jovanović, Milena Savić, Miomir Nikšić, Katarina Anđelković, Tamara Todorović |
Abstract |
In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N'-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 15% |
Professor > Associate Professor | 3 | 12% |
Researcher | 3 | 12% |
Professor | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Other | 5 | 19% |
Unknown | 6 | 23% |
Readers by discipline | Count | As % |
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Chemistry | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Medicine and Dentistry | 3 | 12% |
Agricultural and Biological Sciences | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 4 | 15% |
Unknown | 8 | 31% |