| Title |
Comparison of rapid immunoassays for rupture of fetal membranes
|
|---|---|
| Published in |
BMC Pregnancy and Childbirth, April 2017
|
| DOI | 10.1186/s12884-017-1311-y |
| Pubmed ID | |
| Authors |
Irogue Igbinosa, Ferney A. Moore, Cheri Johnson, Jon E. Block |
| Abstract |
Rupture of membranes (ROM) before the onset of uterine contractions, particularly in pregnancies less than 37 weeks gestational age, is a common diagnostic problem in obstetrical practice. Timely detection of ROM is vital to support gestational age-specific interventions to optimize perinatal outcomes and minimize the risk of serious complications such as preterm delivery, fetal distress and maternal/fetal infections. Rapid bedside immunoassay tests designed to detect amniotic fluid proteins in cervicovaginal fluids have emerged as valuable clinical tools to provide timely ROM diagnosis. In this prospective observational study, two commercially-available immunoassay tests (ROM Plus®, AmniSure®) were evaluated concurrently in 111 pregnant women who presented with the chief complaint of ROM. Immunoassay results were compared to clinical parameters for determining ROM via comprehensive, retrospective clinical chart review. Diagnostic performance characteristics were calculated including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. Overall, diagnostic performance characteristics were robust and similar between ROM Plus® and AmniSure®, respectively: sensitivity (96.4 and 89.3%), specificity (98.8 and 100%), PPV (96.4 and 100%), NPV (98.8% and 96.5) and accuracy (98.2 and 97.3%). For term patients (≥37 weeks gestation), the sensitivities were 93.8 and 81.3% and specificities were 97.1 and 100% for ROM Plus® and AmniSure®, respectively. For preterm patients (<37 weeks gestation), both immunoassay tests provided exact concordance with clinical confirmation of ROM resulting in 100% diagnostic accuracy. Both rapid immunoassay tests provided similarly excellent diagnostic accuracy for the rapid detection of ROM with only two discrepant results for ROM Plus® and three discrepant results for AmniSure® compared to clinical confirmation. The findings from this study recommend these tests for pregnant women presenting with suspected ROM to guide correct clinical management decisions to improve obstetrical and neonatal outcomes. ClinicalTrials.gov, NCT02208011 (1 August 2014). |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 19% |
| Researcher | 7 | 13% |
| Student > Postgraduate | 6 | 11% |
| Other | 4 | 7% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 8 | 15% |
| Unknown | 15 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 44% |
| Nursing and Health Professions | 4 | 7% |
| Psychology | 3 | 6% |
| Mathematics | 1 | 2% |
| Agricultural and Biological Sciences | 1 | 2% |
| Other | 5 | 9% |
| Unknown | 16 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2017.
All research outputs
#18,546,002
of 22,968,808 outputs
Outputs from BMC Pregnancy and Childbirth
#3,497
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Outputs of similar age
#235,315
of 309,828 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#59
of 70 outputs
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