| Title |
Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus
|
|---|---|
| Published in |
Diabetologia, April 2017
|
| DOI | 10.1007/s00125-017-4266-7 |
| Pubmed ID | |
| Authors |
Sujung Yoon, Hanbyul Cho, Jungyoon Kim, Do-Wan Lee, Geon Ha Kim, Young Sun Hong, Sohyeon Moon, Shinwon Park, Sunho Lee, Suji Lee, Sujin Bae, Donald C. Simonson, In Kyoon Lyoo |
| Abstract |
Overweight and obesity may significantly worsen glycaemic and metabolic control in type 2 diabetes. However, little is known about the effects of overweight and obesity on the brains of people with type 2 diabetes. Here, we investigate whether the presence of overweight or obesity influences the brain and cognitive functions during early stage type 2 diabetes. This study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in their brain structures and cognition during early stage type 2 diabetes compared with participants with normal weight. Relationships between each of these measures and disease duration were also examined. Global mean cortical thickness was lower in the overweight/obese type 2 diabetes group than in the normal-weight type 2 diabetes group (z = -2.96, p for group effect = 0.003). A negative correlation was observed between disease duration and global mean white matter integrity (z = 2.42, p for interaction = 0.02) in the overweight/obese type 2 diabetes group, but not in the normal-weight type 2 diabetes group. Overweight/obese individuals with type 2 diabetes showed a decrease in psychomotor speed performance related to disease duration (z = -2.12, p for interaction = 0.03), while normal-weight participants did not. The current study attempted to uncouple the effects of overweight/obesity from those of type 2 diabetes on brain structures and cognition. Overweight/obese participants with type 2 diabetes had more severe and progressive abnormalities in brain structures and cognition during early stage type 2 diabetes compared with normal-weight participants. |
X Demographics
The data shown below were collected from the profiles of 149 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 29 | 19% |
| Canada | 14 | 9% |
| United Kingdom | 11 | 7% |
| France | 5 | 3% |
| Spain | 4 | 3% |
| India | 4 | 3% |
| Brazil | 4 | 3% |
| South Africa | 3 | 2% |
| Netherlands | 3 | 2% |
| Other | 19 | 13% |
| Unknown | 53 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 101 | 68% |
| Practitioners (doctors, other healthcare professionals) | 27 | 18% |
| Scientists | 19 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 79 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 24% |
| Researcher | 10 | 13% |
| Student > Master | 9 | 11% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 23 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 19% |
| Neuroscience | 9 | 11% |
| Nursing and Health Professions | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Psychology | 5 | 6% |
| Other | 14 | 18% |
| Unknown | 26 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 295. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2022.
All research outputs
#110,087
of 24,223,370 outputs
Outputs from Diabetologia
#75
of 5,233 outputs
Outputs of similar age
#2,538
of 313,461 outputs
Outputs of similar age from Diabetologia
#2
of 78 outputs
Altmetric has tracked 24,223,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,233 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,461 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.