| Title |
Apical sparing pattern of left ventricular myocardial 99mTc-HMDP uptake in patients with transthyretin cardiac amyloidosis
|
|---|---|
| Published in |
Journal of Nuclear Cardiology, April 2017
|
| DOI | 10.1007/s12350-017-0894-z |
| Pubmed ID | |
| Authors |
Axel Van Der Gucht, Anne-Ségolène Cottereau, Mukedaisi Abulizi, Aziz Guellich, Paul Blanc-Durand, Jean-Marc Israel, Arnault Galat, Violaine Plante-Bordeneuve, Jean-Luc Dubois-Randé, Diane Bodez, Jean Rosso, Thibaud Damy, Emmanuel Itti |
| Abstract |
A decreased longitudinal strain in basal segments with a base-to-apex gradient has been described in patients with cardiac amyloidosis (CA). Aim was to investigate the left ventricular (LV) regional distribution of early-phase (99m)Tc-Hydroxymethylene diphosphonate ((99m)Tc-HMDP) uptake in patients with transthyretin-related cardiac amyloidosis (TTR-CA). All patients underwent a whole-body planar (99m)Tc-HMDP scintigraphy acquired at 10-min post-injection (early-phase) followed by a thorax SPECT/CT. The segmental uptake (expressed as % of maximal myocardial HMDP uptake) was investigated on the AHA 17-segment model and 3-segment model (basal, mid-cavity, apical). Sixty-one TTR-CA patients were included of whom 29 were wild-type (wt-TTR-CA) and 32 had hereditary TTR-CA (m-TTR-CA). Early myocardial (99m)Tc-HMDP uptake occurred in all TTR-CA. In all patients, segmental analysis of the LV myocardial distribution of (99m)Tc-HMDP uptake showed an increased median uptake (interquartile range) in basal/mid-cavity segments compared to the lowest median uptake of apical segments (respectively, 79% [72%-86%] vs. 72% [64%-81%]; P < 10(-6)). This pattern was similar in wt-TTR-CA group (78% [70%-84%] vs. 70% [61%-81%]; P < 10(-6)), in m-TTR-CA group (80% [74%-86%] vs. 73 [66%-82%]; P < 10(-7)) and remained constant independently of the TTR mutation subtype with P ranging 10(-5) to 0.03. Early-phase myocardial scintigraphy identified regional distribution of (99m)Tc-HMDP uptake characterized by a base-to-apex gradient, corroborating echocardiographic, and cardiac magnetic resonance findings. This apical sparing pattern was similar across TTR-CA and TTR mutation subtypes. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 23% |
| Professor > Associate Professor | 3 | 14% |
| Other | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Student > Bachelor | 1 | 5% |
| Other | 5 | 23% |
| Unknown | 6 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 36% |
| Social Sciences | 3 | 14% |
| Neuroscience | 2 | 9% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Economics, Econometrics and Finance | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 7 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2019.
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#17,289,387
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Outputs from Journal of Nuclear Cardiology
#1,303
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#205,583
of 323,575 outputs
Outputs of similar age from Journal of Nuclear Cardiology
#22
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