Title |
FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
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Published in |
American Journal of Human Biology, December 2013
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DOI | 10.1002/ajhb.22496 |
Pubmed ID | |
Authors |
Tábita Hünemeier, Jorge Gómez‐Valdés, Soledad De Azevedo, Mirsha Quinto‐Sánchez, Luciane Passaglia, Francisco M. Salzano, Gabriela Sánchez‐Mejorada, Víctor Acuña Alonzo, Neus Martínez‐Abadías, Maria‐Cátira Bortolini, Rolando González‐José |
Abstract |
The head can be used as a model to study complex phenotypes controlled simultaneously by morphological integration (MI) due to common factors, and modular patterns caused by local factors affecting the development and functional demands of specific structures. The fibroblast growth factor and receptor system (FGF/FGFR) participates in cell communication and pattern formation in osseous tissues, among others, and there is compelling evidence from mouse model studies suggesting a role of the FGF/FGFR pathway as a covariance-generating signaling process in head development. Here we use human data to test if specific genetic variants of another gene of this pathway, the FGFR1 gene, can be associated with differences in the integration of the head. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 2 | 7% |
Unknown | 28 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 23% |
Researcher | 7 | 23% |
Student > Bachelor | 3 | 10% |
Other | 3 | 10% |
Lecturer | 1 | 3% |
Other | 4 | 13% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 43% |
Medicine and Dentistry | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Environmental Science | 1 | 3% |
Unspecified | 1 | 3% |
Other | 4 | 13% |
Unknown | 6 | 20% |