Title |
Imaging Microglial Activation During Neuroinflammation and Alzheimer’s Disease
|
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Published in |
Journal of Neuroimmune Pharmacology, December 2008
|
DOI | 10.1007/s11481-008-9142-2 |
Pubmed ID | |
Authors |
Sriram Venneti, Clayton A. Wiley, Julia Kofler |
Abstract |
Microglial activation is an important pathogenic component of neurodegenerative disease processes. This state of increased inflammation is associated not only with neurotoxic consequences but also neuroprotective effects, e.g., phagocytosis and clearance of amyloid in Alzheimer's disease. In addition, activation of microglia appears to be one of the major mechanisms of amyloid clearance following active or passive immunotherapy. Imaging techniques may provide a minimally invasive tool to elucidate the complexities and dynamics of microglial function and dysfunction in aging and neurodegenerative diseases. Imaging microglia in vivo in live subjects by confocal or two/multiphoton microscopy offers the advantage of studying these cells over time in their native environment. Imaging microglia in human subjects by positron emission tomography scanning with translocator protein-18 kDa ligands can offer a measure of the inflammatory process and a means of detecting progression of disease and efficacy of therapeutics over time. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Japan | 2 | 1% |
Uruguay | 1 | <1% |
United Kingdom | 1 | <1% |
Chile | 1 | <1% |
Belgium | 1 | <1% |
Netherlands | 1 | <1% |
Mexico | 1 | <1% |
Spain | 1 | <1% |
Other | 0 | 0% |
Unknown | 146 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 19% |
Researcher | 29 | 18% |
Student > Bachelor | 21 | 13% |
Student > Master | 20 | 13% |
Student > Postgraduate | 9 | 6% |
Other | 27 | 17% |
Unknown | 22 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 49 | 31% |
Medicine and Dentistry | 38 | 24% |
Neuroscience | 16 | 10% |
Biochemistry, Genetics and Molecular Biology | 7 | 4% |
Psychology | 4 | 3% |
Other | 13 | 8% |
Unknown | 31 | 20% |