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Characterization of cytoplasmic hyaline bodies in a hepatocellular carcinoma of a dog

Overview of attention for article published in Research in Veterinary Science, December 2013
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Title
Characterization of cytoplasmic hyaline bodies in a hepatocellular carcinoma of a dog
Published in
Research in Veterinary Science, December 2013
DOI 10.1016/j.rvsc.2013.11.016
Pubmed ID
Authors

Carlo Masserdotti, Enrica Rossetti, Davide De Lorenzi, Leonardo Della Salda, Chiara Palmieri

Abstract

This report describes the morphological and immunohistochemical features of intracytoplasmic inclusion bodies found in a 13-year-old Yorkshire dog with a hepatocellular carcinoma and referred for anorexia, lethargy and mild polydipsia. Fine-needle aspirates of the large abdominal mass revealed high number of pleomorphic neoplastic hepatocytes, containing round to polygonal, well-demarcated, hyaline bodies. Same findings were histologically confirmed on multiple biopsies. Immunohistochemically, the inclusion bodies were negative for alpha-1-antitrypsin, carcinoembryonary antigen, fibrinogen, IgG, IgM, cytokeratins 7, 8, 18, 19, 20. By transmission electron microscopy, the cytoplasmic inclusions were composed of granular homogeneous or reticulated electrondense matrix, enclosed within dilated rough endoplasmic reticulum or remnants of its membranes, consistent with proteinaceous material accumulated within neoplastic hepatocytes due to aberrant protein secretion or transport. This is the first detailed characterization of hyaline cytoplasmic inclusion bodies in canine hepatocellular carcinoma.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 6 27%
Professor > Associate Professor 3 14%
Student > Master 3 14%
Other 2 9%
Researcher 2 9%
Other 2 9%
Unknown 4 18%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 11 50%
Medicine and Dentistry 5 23%
Agricultural and Biological Sciences 1 5%
Unknown 5 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2013.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Research in Veterinary Science
#1,744
of 2,351 outputs
Outputs of similar age
#281,940
of 320,286 outputs
Outputs of similar age from Research in Veterinary Science
#11
of 14 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,351 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.