You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Globally Disseminated M1T1 Clone of Group A Streptococcus Evades Autophagy for Intracellular Replication
|
|---|---|
| Published in |
Cell Host & Microbe (Science Direct), December 2013
|
| DOI | 10.1016/j.chom.2013.11.003 |
| Pubmed ID | |
| Authors |
Timothy C. Barnett, David Liebl, Lisa M. Seymour, Christine M. Gillen, Jin Yan Lim, Christopher N. LaRock, Mark R. Davies, Benjamin L. Schulz, Victor Nizet, Rohan D. Teasdale, Mark J. Walker |
| Abstract |
Autophagy is reported to be an important innate immune defense against the intracellular bacterial pathogen Group A Streptococcus (GAS). However, the GAS strains examined to date belong to serotypes infrequently associated with human disease. We find that the globally disseminated serotype M1T1 clone of GAS can evade autophagy and replicate efficiently in the cytosol of infected cells. Cytosolic M1T1 GAS (strain 5448), but not M6 GAS (strain JRS4), avoids ubiquitylation and recognition by the host autophagy marker LC3 and ubiquitin-LC3 adaptor proteins NDP52, p62, and NBR1. Expression of SpeB, a streptococcal cysteine protease, is critical for this process, as an isogenic M1T1 ΔspeB mutant is targeted to autophagy and attenuated for intracellular replication. SpeB degrades p62, NDP52, and NBR1 in vitro and within the host cell cytosol. These results uncover a proteolytic mechanism utilized by GAS to escape the host autophagy pathway that may underpin the success of the M1T1 clone. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Mexico | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 83% |
| Members of the public | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Taiwan | 1 | <1% |
| Unknown | 99 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 25% |
| Researcher | 15 | 15% |
| Student > Master | 13 | 13% |
| Student > Bachelor | 8 | 8% |
| Student > Postgraduate | 8 | 8% |
| Other | 15 | 15% |
| Unknown | 17 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 26% |
| Biochemistry, Genetics and Molecular Biology | 20 | 20% |
| Immunology and Microbiology | 18 | 18% |
| Medicine and Dentistry | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 8 | 8% |
| Unknown | 18 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2014.
All research outputs
#1,217,300
of 25,371,288 outputs
Outputs from Cell Host & Microbe (Science Direct)
#802
of 2,625 outputs
Outputs of similar age
#13,002
of 320,954 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#8
of 27 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,625 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.6. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.