| Title |
Quantification of renal function following stereotactic body radiotherapy for pancreatic cancer: secondary dosimetric analysis of a prospective clinical trial
|
|---|---|
| Published in |
Radiation Oncology, April 2017
|
| DOI | 10.1186/s13014-017-0798-8 |
| Pubmed ID | |
| Authors |
Vivek Verma, Abhijeet R. Bhirud, Kyle A. Denniston, Nathan R. Bennion, Chi Lin |
| Abstract |
This is the first known study examining renal function following stereotactic body radiotherapy (SBRT) for pancreatic head adenocarcinoma. Thirty-eight borderline-resectable/unresectable patients, part of an ongoing prospective trial, underwent 3 cycles of gemcitabine/5-fluorouracil followed by SBRT (5 daily fractions of 5/6/7/8 Gy) and concurrent nelfinavir. Thereafter, in resectable cases, surgery was performed within 4-8 weeks. The last available pre-SBRT creatinine was recorded, along with the highest post-SBRT value. Glomerular filtration rate (GFR) was calculated by the commonly-utilized Modification of Diet in Renal Disease formula. GFR decline was defined as the post-SBRT nadir GFR minus the pre-SBRT GFR. Correlations with the V5-V30, and mean/maximum kidney doses was performed. Statistics included Pearson correlation, Mann-Whitney, and Fisher's exact tests. The median total kidney volume was 355 cm(3). Median dosimetric values were as follows: V5 (209 cm(3)), V10 (103 cm(3)), V15 (9 cm(3)), V20 (0 cm(3)), V25 (0 cm(3)); and mean (6.7 Gy) & maximum kidney dose (18.3 Gy). Median GFR change was -23 (range, -105 to 25) mL/min/1.73 cm(2). Of all dosimetric parameters, only V5 was significantly associated with changes in GFR (Pearson r = -0.40, p = 0.012). In patients with V5 < 210 cm(3), median GFR change was -11.8 mL/min/1.73 cm(2), as compared with -37.1 mL/min/1.73 cm(2) change in those with V5 ≥ 210 cm(3) (p = 0.02). A GFR change < -23 mL/min/1.73 cm(2) was observed in 6/20 (30%) patients with V5 < 210 cm(3), versus 15/18 (83%) of those with V5 ≥ 210 cm(3). Patients with V5 ≥ 210 cm(3) were over ten times as likely to have GFR change < -23 mL/min/1.73 cm(2) (p = 0.003). Using linear regression, GFR change ≈ -0.1748 × V5(cm(3)) + 8.63. In the first known analysis of renal function after pancreatic SBRT, evaluating patients on a prospective study, V5 ≥ 210 cm(3) was associated with a post-SBRT GFR decline of >23 mL/min/1.73 cm(2). If V5 is kept <210 cm(3), median GFR decline was only 11.8 mL/min/1.73 cm(2). Further validation is needed to ascertain definite dose-volume parameters and examine late renal decline. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 18% |
| Other | 5 | 13% |
| Student > Master | 5 | 13% |
| Researcher | 3 | 8% |
| Professor | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 11 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 34% |
| Nursing and Health Professions | 5 | 13% |
| Psychology | 2 | 5% |
| Immunology and Microbiology | 1 | 3% |
| Physics and Astronomy | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 12 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2017.
All research outputs
#20,418,183
of 22,968,808 outputs
Outputs from Radiation Oncology
#1,689
of 2,066 outputs
Outputs of similar age
#269,443
of 309,813 outputs
Outputs of similar age from Radiation Oncology
#17
of 23 outputs
Altmetric has tracked 22,968,808 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,066 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,813 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.