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CMAJ

Use of antibiotics during pregnancy and risk of spontaneous abortion

Overview of attention for article published in Canadian Medical Association Journal, April 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
73 news outlets
blogs
4 blogs
policy
2 policy sources
twitter
117 X users
facebook
32 Facebook pages
googleplus
2 Google+ users
video
1 YouTube creator

Citations

dimensions_citation
101 Dimensions

Readers on

mendeley
212 Mendeley
Title
Use of antibiotics during pregnancy and risk of spontaneous abortion
Published in
Canadian Medical Association Journal, April 2017
DOI 10.1503/cmaj.161020
Pubmed ID
Authors

Flory T. Muanda, Odile Sheehy, Anick Bérard

Abstract

Although antibiotics are widely used during pregnancy, evidence regarding their fetal safety remains limited. Our aim was to quantify the association between antibiotic exposure during pregnancy and risk of spontaneous abortion. We conducted a nested case-control study within the Quebec Pregnancy Cohort (1998-2009). We excluded planned abortions and pregnancies exposed to fetotoxic drugs. Spontaneous abortion was defined as having a diagnosis or procedure related to spontaneous abortion before the 20th week of pregnancy. The index date was defined as the calendar date of the spontaneous abortion. Ten controls per case were randomly selected and matched by gestational age and year of pregnancy. Use of antibiotics was defined by filled prescriptions between the first day of gestation and the index date and was compared with (a) non-exposure and (b) exposure to penicillins or cephalosporins. We studied type of antibiotics separately using the same comparator groups. After adjustment for potential confounders, use of azithromycin (adjusted odds ratio [OR] 1.65, 95% confidence interval [CI] 1.34-2.02; 110 exposed cases), clarithromycin (adjusted OR 2.35, 95% CI 1.90-2.91; 111 exposed cases), metronidazole (adjusted OR 1.70, 95% CI 1.27-2.26; 53 exposed cases), sulfonamides (adjusted OR 2.01, 95% CI 1.36-2.97; 30 exposed cases), tetracyclines (adjusted OR 2.59, 95% CI 1.97-3.41; 67 exposed cases) and quinolones (adjusted OR 2.72, 95% CI 2.27-3.27; 160 exposed cases) was associated with an increased risk of spontaneous abortion. Similar results were found when we used penicillins or cephalosporins as the comparator group. After adjustment for potential confounders, use of macro-lides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion. Our findings may be of use to policy-makers to update guidelines for the treatment of infections during pregnancy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 117 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 211 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 31 15%
Student > Master 27 13%
Student > Ph. D. Student 26 12%
Researcher 19 9%
Other 18 8%
Other 42 20%
Unknown 49 23%
Readers by discipline Count As %
Medicine and Dentistry 79 37%
Pharmacology, Toxicology and Pharmaceutical Science 21 10%
Nursing and Health Professions 14 7%
Agricultural and Biological Sciences 11 5%
Immunology and Microbiology 8 4%
Other 21 10%
Unknown 58 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 658. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2023.
All research outputs
#32,916
of 25,525,181 outputs
Outputs from Canadian Medical Association Journal
#55
of 9,489 outputs
Outputs of similar age
#641
of 324,503 outputs
Outputs of similar age from Canadian Medical Association Journal
#4
of 117 outputs
Altmetric has tracked 25,525,181 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,489 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.