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Coronary Artery Calcification From Mechanism to Molecular Imaging

Overview of attention for article published in JACC: Cardiovascular Imaging, May 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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1 news outlet
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121 X users
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9 Facebook pages

Citations

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275 Dimensions

Readers on

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345 Mendeley
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Title
Coronary Artery Calcification From Mechanism to Molecular Imaging
Published in
JACC: Cardiovascular Imaging, May 2017
DOI 10.1016/j.jcmg.2017.03.005
Pubmed ID
Authors

Takehiro Nakahara, Marc R. Dweck, Navneet Narula, David Pisapia, Jagat Narula, H. William Strauss

Abstract

Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence of calcification may change portions of the arterial conduit to a noncompliant structure. Calcifications may also seed the cap of a thin cap fibroatheroma, altering tensile forces on the cap and rendering the lesion prone to rupture. Many local and systemic factors participate in this process, including hyperlipidemia, ongoing inflammation, large necrotic cores, and diabetes. Vascular cells can undergo chondrogenic or osteogenic differentiation, causing mineralization of membranous bone and formation of endochondral bone. Calcifying vascular cells are derived from local smooth muscle cells and circulating hematopoietic stem cells (especially in intimal calcification). Matrix vesicles in the extracellular space of the necrotic core serve as a nidus for calcification. Although coronary calcification is a marker of coronary atheroma, dense calcification (>400 HU) is usually associated with stable plaques. Conversely, microcalcification (often also referred to as spotty calcification) is more commonly an accompaniment of vulnerable plaques. Recent studies have suggested that microcalcification in the fibrous cap may increase local tissue stress (depending on the proximity of one microcalcific locus to another, and the orientation of the microcalcification in reference to blood flow), resulting in plaque instability. It has been proposed that positron emission tomography imaging with sodium fluoride may identify early calcific deposits and hence high-risk plaques.

X Demographics

X Demographics

The data shown below were collected from the profiles of 121 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 345 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 345 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 43 12%
Student > Ph. D. Student 41 12%
Student > Master 28 8%
Researcher 27 8%
Student > Doctoral Student 21 6%
Other 52 15%
Unknown 133 39%
Readers by discipline Count As %
Medicine and Dentistry 107 31%
Biochemistry, Genetics and Molecular Biology 26 8%
Engineering 14 4%
Pharmacology, Toxicology and Pharmaceutical Science 9 3%
Nursing and Health Professions 9 3%
Other 32 9%
Unknown 148 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2023.
All research outputs
#556,918
of 25,443,857 outputs
Outputs from JACC: Cardiovascular Imaging
#128
of 2,705 outputs
Outputs of similar age
#11,460
of 324,748 outputs
Outputs of similar age from JACC: Cardiovascular Imaging
#3
of 52 outputs
Altmetric has tracked 25,443,857 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,705 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,748 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.