| Title |
Metformin: New Preparations and Nonglycemic Benefits
|
|---|---|
| Published in |
Current Diabetes Reports, January 2017
|
| DOI | 10.1007/s11892-017-0829-8 |
| Pubmed ID | |
| Authors |
Yoshihito Fujita, Nobuya Inagaki |
| Abstract |
Metformin has been widely used for over 5 decades. New preparations have been developed for possible enhancement of efficiency, tolerability, and pleiotropic nonglycemic effects. Extended-release metformin has contributed to adherence and improved gastrointestinal tolerability. Delayed-release metformin acts in the lower gastrointestinal tract and exerts glucose-lowering effects at lower plasma metformin levels, which might suggest use of this biguanide in patients with chronic kidney disease. Metformin is also known to have numerous nonglycemic effects. Results of the UK Prospective Diabetes Study indicate improvements in cardiovascular outcome and reduced total mortality independent of glycemic control. Anticancer effects of metformin have been discussed and many clinical trials are on-going. Metformin is noted for its beneficial effects on lifespan extension and on disorders due to increased insulin resistance. Further investigations, including randomized control trials in nondiabetic individuals, are required to demonstrate the nonglycemic effects of metformin. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 33% |
| Chile | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 171 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 16% |
| Student > Master | 20 | 12% |
| Student > Ph. D. Student | 18 | 11% |
| Researcher | 14 | 8% |
| Student > Postgraduate | 11 | 6% |
| Other | 27 | 16% |
| Unknown | 54 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 30% |
| Pharmacology, Toxicology and Pharmaceutical Science | 21 | 12% |
| Biochemistry, Genetics and Molecular Biology | 16 | 9% |
| Nursing and Health Professions | 7 | 4% |
| Social Sciences | 4 | 2% |
| Other | 12 | 7% |
| Unknown | 59 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2021.
All research outputs
#5,589,787
of 22,968,808 outputs
Outputs from Current Diabetes Reports
#271
of 1,014 outputs
Outputs of similar age
#104,132
of 419,148 outputs
Outputs of similar age from Current Diabetes Reports
#6
of 14 outputs
Altmetric has tracked 22,968,808 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,014 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,148 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.