| Title |
Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats
|
|---|---|
| Published in |
Psychopharmacology, May 2017
|
| DOI | 10.1007/s00213-017-4632-7 |
| Pubmed ID | |
| Authors |
Amy A. Arguello, Rong Wang, Carey M. Lyons, Jessica A. Higginbotham, Matthew A. Hodges, Rita A. Fuchs |
| Abstract |
Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine memory reconsolidation. Rats were trained to lever press for cocaine infusions in a distinctive context, followed by extinction training in a different context. Rats in experiment 1 received bilateral microinfusions of vehicle or a GABA agonist cocktail (baclofen and muscimol (BM)) into the AI or the overlying somatosensory cortex (SSJ, anatomical control region) immediately before a test of drug-seeking behavior (i.e., non-reinforced lever presses) in the previously cocaine-paired context. The effects of these manipulations on locomotor activity were also assessed in a novel context. Rats in experiment 2 received vehicle or BM into the AI after a 15-min reexposure to the cocaine-paired context, intended to reactivate context-response-cocaine memories and initiate their reconsolidation. The effects of these manipulations on drug context-induced cocaine-seeking behavior were assessed 72 h later. BM-induced pharmacological inactivation of the AI, but not the SSJ, attenuated drug context-induced reinstatement of cocaine-seeking behavior without altering locomotor activity. Conversely, AI inactivation after memory reactivation failed to impair subsequent drug-seeking behavior and thus cocaine memory reconsolidation. These findings suggest that the AI is a critical element of the neural circuitry that mediates contextual control over cocaine-seeking behavior. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 23% |
| Student > Bachelor | 8 | 15% |
| Researcher | 7 | 13% |
| Student > Master | 6 | 12% |
| Student > Doctoral Student | 5 | 10% |
| Other | 5 | 10% |
| Unknown | 9 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 40% |
| Agricultural and Biological Sciences | 7 | 13% |
| Psychology | 4 | 8% |
| Medicine and Dentistry | 2 | 4% |
| Environmental Science | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 13 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2017.
All research outputs
#15,457,417
of 22,968,808 outputs
Outputs from Psychopharmacology
#4,264
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Outputs of similar age
#194,775
of 310,760 outputs
Outputs of similar age from Psychopharmacology
#30
of 61 outputs
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