| Title |
Liquid biopsy: unlocking the potentials of cell-free DNA
|
|---|---|
| Published in |
Virchows Archiv, May 2017
|
| DOI | 10.1007/s00428-017-2137-8 |
| Pubmed ID | |
| Authors |
David Chu, Ben Ho Park |
| Abstract |
Circulating tumor DNA (ctDNA) has garnered much excitement over the past few years for its potential clinical utility as a surrogate for tumor biopsies in early cancer detection and prognosis. Numerous studies have demonstrated that ctDNA is shed into the circulation and is elevated in disease states such as cancer. Despite the low levels of ctDNA in the "sea" of normal DNA, advances in next generation sequencing (NGS) and digital polymerase chain reaction (PCR) technologies have led to dramatic improvements in variant detection sensitivity and specificity. These technologies allow the quantification of ctDNA, providing both prognostic and predictive information. Here, we review the history of cell-free DNA and different technologies for the detection of ctDNA in cancer and describe the different modalities for using ctDNA in clinical oncology. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 17% |
| Sweden | 1 | 17% |
| Malaysia | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 95 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 15% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Master | 10 | 11% |
| Student > Bachelor | 10 | 11% |
| Other | 10 | 11% |
| Other | 17 | 18% |
| Unknown | 23 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 24% |
| Medicine and Dentistry | 21 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Immunology and Microbiology | 5 | 5% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 8 | 8% |
| Unknown | 28 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2022.
All research outputs
#4,670,820
of 23,758,679 outputs
Outputs from Virchows Archiv
#175
of 2,027 outputs
Outputs of similar age
#79,524
of 312,091 outputs
Outputs of similar age from Virchows Archiv
#4
of 54 outputs
Altmetric has tracked 23,758,679 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,027 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.