Title |
Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
|
---|---|
Published in |
Journal of Autism and Developmental Disorders, December 2013
|
DOI | 10.1007/s10803-013-2017-2 |
Pubmed ID | |
Authors |
Kristen Lyall, Paul Ashwood, Judy Van de Water, Irva Hertz-Picciotto |
Abstract |
The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 20% |
United States | 1 | 20% |
Canada | 1 | 20% |
Ireland | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 2 | 1% |
United States | 2 | 1% |
Mexico | 1 | <1% |
Unknown | 170 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 18% |
Student > Master | 23 | 13% |
Student > Bachelor | 21 | 12% |
Student > Doctoral Student | 17 | 10% |
Researcher | 16 | 9% |
Other | 30 | 17% |
Unknown | 36 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 42 | 24% |
Psychology | 25 | 14% |
Neuroscience | 18 | 10% |
Agricultural and Biological Sciences | 17 | 10% |
Biochemistry, Genetics and Molecular Biology | 10 | 6% |
Other | 25 | 14% |
Unknown | 38 | 22% |